transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2022-9-6-5-15transmed-738Research ArticleОНКОЛОГИЧЕСКИЕ ЗАБОЛЕВАНИЯCANCERБелки теплового шока в качестве диагностических и прогностических маркеров при злокачественных опухолях центральной нервной системыHeat shock proteins as diagnostic and prognostic markers in malignant tumors of the central nervous systemНазаралиеваЭ. Т.NazaralievaE. T.

Назаралиева Элеонора Тууганбаевна, к.м.н., научный сотрудник НИЛ нейрохирургии детского возраста

ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341

Eleonora T. Nazaralieva, MD, Researcher, Research Laboratory of Pediatric Neurosurgery

Akkuratova str., 2, Saint Petersburg, Russia, 197341

neleonora@yandex.ruФедоровВ. С.FedorovV. S.

Федоров Вячеслав Сергеевич, старший лаборант-исследователь 

Санкт-Петербург

Vyacheslav S. Fedorov, senior laboratory assistantresearcher

Saint Petersburg

fedorovvs.biotech@gmail.comЗабродскаяЮ. М.ZabrodskayaYu. M.

Забродская Юлия Михайловна, д.м.н., заведующий НИЛ патоморфологии нервной системы

Санкт-Петербург

Yulia M. Zabrodskaya, ScD, Head of the Research Laboratory of Pathomorphology of the Nervous System

Saint Petersburg

zabrjulia@yandex.ruКимА. В.KimA. V.

Ким Александр Вонгиевич, д.м.н., доцент кафедры нейрохирургии, заведующий ДНХО № 7

Санкт-Петербург

Alexander V. Kim, ScD, Associate Professor, Department of Neurosurgery, Head of the Children’s Neurosurgical Department № 7

Saint Petersburg

kimoza@mail.ruДжаналиевБ. Р.DjanalievB. R.

Джаналиев Болот Рахманович, д.м.н., профессор кафедры патологической анатомии 

Бишкек

Bolot R. Djanaliev, ScD, Professor, Department of Pathological Anatomy

Bishkek

bolotdjanaliev5@gmail.comШевцовМ. А.ShevtsovM. A.

Шевцов Максим Алексеевич, д.б.н., ведущий научный сотрудник; заведующий НИО трансляционной онкологии НЦМУ «Центр персонализированной медицины»

Санкт-Петербург

Maxim A. Shevtsov, ScD, Leading Researcher, Institute of Cytology of the Russian Academy of Sciences; Head of Research Center for Translational Oncology

Saint Petersburg

shevtsov-max@mail.ruСамочерныхК. А.SamochernychK. A.

Самочерных Константин Александрович, д.м.н., профессор РАН, директор, заведующий научно-исследовательским центром персонализированной онкологии НЦМУ «Центр персонализированной медицины»

Санкт-Петербург

Konstantin A. Samochernych, ScD, professor of the Russian Academy of Sciences, director, Head of the Research Center for Personalized Oncology, World-Class Research Centre for Personalized Medicine

Saint Petersburg

neurobaby12@gmail.comРоссийский научно-исследовательский нейрохирургический институт имени профессора А. Л. Поленова — филиал Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияPolenov Russian Scientific Research Institute of NeurosurgeryRussian FederationФедеральное государственное бюджетное учреждение науки «Институт цитологии Российской академии наук»РоссияInstitute of Cytology of the Russian Academy of ScienceRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации, Научный центр мирового уровня «Центр персонализированной медицины»РоссияAlmazov National Medical Research Centre, World-Class Research Centre for Personalized MedicinRussian FederationКыргызская государственная медицинская академия им. И.К. АхунбаеваKyrgyzstanФедеральное государственное бюджетное учреждение науки «Институт цитологии Российской академии наук»; Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации, Научный центр мирового уровня «Центр персонализированной медицины»РоссияInstitute of Cytology of the Russian Academy of Science; Almazov National Medical Research Centre, World-Class Research Centre for Personalized MedicinRussian Federation20220203202396515Copyright © Назаралиева Э.Т., Федоров В.С., Забродская Ю.М., Ким А.В., Джаналиев Б.Р., Шевцов М.А., Самочерных К.А., 20232023Назаралиева Э.Т., Федоров В.С., Забродская Ю.М., Ким А.В., Джаналиев Б.Р., Шевцов М.А., Самочерных К.А.Nazaralieva E.T., Fedorov V.S., Zabrodskaya Y.M., Kim A.V., Djanaliev B.R., Shevtsov M.A., Samochernych K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/738

В настоящем обзоре представлены литературные данные об эпидемиологии злокачественных опухолей центральной нервной системы, определено значение молекулярной диагностики и экспрессии белков теплового шока в туморогенезе. Особое внимание уделяется описанию молекулярных шаперонов в качестве диагностических и прогностических маркеров, а также перспективам использования шаперонов в персонализированной терапии опухолей центральной нервной системы. Поиск литературы, как отечественной, так и зарубежной, опубликованной в период с 1988 по 2022 годы, осуществлялся на платформах баз данных Medline (через PubMed) и Scopus, Cochrane Library, The Lancet Public Health Journal. Поиск материала проводился по ключевым словам и терминам, включающим «белки теплового шока», «опухоли центральной нервной системы», «опухоли головного мозга», «молекулярная диагностика», «экспрессия молекулярных шаперонов», HSP110, HSP90, HSP70, HSP60, HSP40, small HSPs.

Молекулярные шапероны из-за их важной роли в физиологических процессах в клетке высоко экспрессируются в опухолях головного мозга, а уровень экспрессии HSPs сильно коррелирует со степенью злокачественности, инвазивным потенциалом, а также устойчивостью к радиохимиотерапии. Для некоторых представителей HSPs (то есть HSP10, HSPB1, DNAJC10, HSPA7, HSP90) выявлена прямая корреляция между уровнем экспрессии белка (на основе анализа IHC) и плохим общим прогнозом выживаемости для пациентов с глиальными опухолями. Это указывает на прогностические значения этих маркеров, которые в будущем могут быть включены в диагностическую панель при исследовании образца опухоли.

 

This review overview current epidemiology data of malignant tumors of the central nervous system, and determines the significance of molecular diagnostics and expression of heat shock proteins in tumorigenesis. Particular attention is paid to the description of molecular chaperones as diagnostic and prognostic markers, as well as the prospects for chaperones using in personalized therapy the central nervous system tumors. The search for literature was carried out on the database platforms Medline (via PubMed) and Scopus, Cochrane Library, The Lancet Public Health Journal published between 1988 and 2022. The material was searched for keywords and terms, including “heat shock proteins”, “tumors of the central nervous system”, “brain tumors”, “molecular diagnostics”, “expression of molecular chaperones”, Hsp110, Hsp90, Hsp70, Hsp60, Hsp40, small HSPs. Molecular chaperones, due to their important role in physiological processes in the cell, are highly expressed in brain tumors, and the expression level of HSPs strongly correlates with the degree of malignancy, invasive potential, and resistance to radiochemotherapy. For some HSPs (i.e. HSP10, HSPB1, DNAJC10, HSPA7, HSP90) a direct correlation has been found between the level of protein expression (based on IHC analysis) and a poor overall survival prognosis for patients with glial tumors. This indicates the prognostic value of these markers, which in the future may be included in the diagnostic panel when examining a tumor sample.

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The authors declare that there are no conflicts of interest present.