transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2022-9-5-33-43transmed-722Research ArticleСЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯCARDIOVASCULAR MEDICINEОценка глобальной, сегментарной продольной деформации левого желудочка и функции эндотелия у детей с семейной гиперхолестеринемиейAssessment of global, segmental longitudinal deformation of the left ventricle and endothelial function in children with family hypercholesterolemiahttps://orcid.org/0000-0002-6662-3548ГалимоваЛ. Ф.GalimovaL. F.

к.м.н., заведующая отделением ультразвуковой диагностики Детской республиканской клинической больницы, ассистент кафедры госпитальной педиатрии

ул. Оренбургский тракт, 140, Казань, Республика Татарстан, 420138

тел. +79272499471

Liliya F. Galimova, PhD, doctor of ultrasound diagnostics, Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, assistant of the Department of Hospital Pediatrics, Kazan State Medical University

Str. Orenburgskiy trakt, 140, Kazan, 420138

lilu1@inbox.ruhttps://orcid.org/0000-0002-6662-3548СадыковаД. И.SadykovaD. I.

Садыкова Динара Ильгизаровна, д.м.н., заведующий кафедрой госпитальной педиатрии

Казань

Dinara I. Sadykova, MD, head of Department of Hospital Pediatrics

Kazan

sadykovadi@mail.ruhttps://orcid.org/0000-0002-5722-8490МакароваТ. П.MakarovaT. P.

Макарова Тамара Петровна, д.м.н., профессор кафедры госпитальной педиатрии

Казань

Tamara P. Makarova, MD, Professor of the Department of Hospital Pediatrics

Kazan

Makarova-kgmu@mail.ruhttps://orcid.org/0000-0002-2957-680XКамаловаА. А.KamalovaA. A.

Камалова Аэлита Асхатовна, д.м.н., профессор кафедры госпитальной педиатрии

Казань

Aelita A. Kamalova, MD, professor of the Department of Hospital Pediatrics

Kazan

aelitakamalova@gmail.comhttps://orcid.org/0000-0001-6633-6381МельниковаЮ. С.MelnikovaYu. S.

Мельникова Юлия Сергеевна, к.м.н., ассистент кафедры госпитальной педиатрии

Казань

Yulia S. Melnikova, PhD, assistant of the Department of Hospital Pediatrics

Kazan

mus87@mail.ruhttps://orcid.org/0000-0002-1732-7443СластниковаЕ. С.SlastnikovaE. S.

Сластникова Евгения Сергеевна, к.м.н., врач ГАУЗ «Детская республиканская клиническая больница Минздрава Республики Татарстан», ассистент кафедры госпитальной педиатрии Казанского государственного медицинского университета

Казань

Evgenia S. Slastnikova, PhD, assistant of the Department of Hospital Pediatrics

Kazan

e.slastnikova@mail.ruhttps://orcid.org/0000-0001-6107-2233РахмаеваР. Ф.RakhmaevaR. F.

Рахмаева Разиля Фоатовна, к.м.н., ассистент кафедры госпитальной педиатрии

Казань

Razilya F. Rakhmaeva, PhD, assistant of the Department of Hospital Pediatrics

Kazan

r.rakhmaeva@mail.ruhttps://orcid.org/0000-0001-5609-135XПетроваМ. А.PetrovaM. A.

Петрова Мария Алексеевна, врач ГАУЗ «Детская республиканская клиническая больница Минздрава Республики Татарстан», аспирант кафедры госпитальной педиатрии

Казань

Maria A. Petrova, doctor, Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, postgraduate student, Department of Hospital Pediatrics, Kazan State Medical University

Kazan

M_Allik95@mail.ruhttps://orcid.org/0000-0003-4289-0841МустафаеваА. А.MustafayevaA. A.

Мустафаева Альмира Анасовна, к.м.н., заместитель главного врача

Казань

Almira A. Mustafayeva, MD, deputy chief physician

Kazan

Almira.Mustafaeva@tatar.ruhttps://orcid.org/0000-0002-6668-0411СеменоваГ. Г.SemenovaG. G.

Семенова Гульнур Гарифулловна, заведующий поликлиникой «Азино»

Казань

Gulnur G. Semenova, head of the Azino Polyclinic

Kazan

Gulnur.Semenova@tatar.ruГосударственное автономное учреждение здравоохранения «Детская республиканская клиническая больница Министерства здравоохранения Республики Татарстан»; Федеральное государственное бюджетное образовательное учреждение высшего образования «Казанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияChildren’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan; Kazan State Medical UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Казанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKazan State Medical UniversityRussian FederationГосударственное автономное учреждение здравоохранения «Детская республиканская клиническая больница Министерства здравоохранения Республики Татарстан»РоссияChildren’s Republican Clinical Hospital of the Ministry of Health of the Republic of TatarstanRussian Federation202228122022953343Copyright © Галимова Л.Ф., Садыкова Д.И., Макарова Т.П., Камалова А.А., Мельникова Ю.С., Сластникова Е.С., Рахмаева Р.Ф., Петрова М.А., Мустафаева А.А., Семенова Г.Г., 20232023Галимова Л.Ф., Садыкова Д.И., Макарова Т.П., Камалова А.А., Мельникова Ю.С., Сластникова Е.С., Рахмаева Р.Ф., Петрова М.А., Мустафаева А.А., Семенова Г.Г.Galimova L.F., Sadykova D.I., Makarova T.P., Kamalova A.A., Melnikova Y.S., Slastnikova E.S., Rakhmaeva R.F., Petrova M.A., Mustafayeva A.A., Semenova G.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/722Актуальность

Актуальность. Семейная гиперхолестеринемия (СГХС) сопровождается значительным повышением уровня холестерина липопротеидов низкой плотности в крови. Актуальность своевременной диагностики и лечения обусловлена риском преждевременного развития атеросклероза. Среди пациентов с СГХС до 30 лет встречается ишемическая болезнь сердца вследствие атеросклероза коронарных артерий. В настоящее время недостаточно сведений о сердечной морфологии и функции миокарда при СГХС в детском возрасте.  

Цель

Цель. Оценить глобальную, сегментарную продольную деформацию левого желудочка и функцию эндотелия у детей с семейной гиперхолестеринемией.  

Материалы и методы

Материалы и методы. В исследовании участвовали 59 детей, из них 25 здоровых ребят (контрольная группа) и 34 человека с диагнозом «гетерозиготная семейная гиперхолестеринемия». Эндотелин-1 и оксид азота определяли методом иммуноферментного анализа. Эхокардиографическое исследование проводилось по стандартной методике. Оценка глобальной и сегментарной продольной деформации левого желудочка проводилась в 4-х камерной апикальной, 3-х камерной и 2-х камерной проекциях с использованием автоматизированного инструмента измерения TOMTEC Autostrain LV.  

Результаты

Результаты. Статистически значимых различий глобальной продольной деформации (ГПД) между детьми контрольной группы и с СГХС не выявлено. Индивидуальный анализ показал, что у 2 пациентов с СГХС отмечалось снижение ГПД. Анализ сегментарной продольной деформации выявил статистически значимое снижение показателей у пациентов с СГХС на уровне базального и апикального передне-перегородочных, базального нижнего сегментов. Оценка эндотелина-1 и оксида азота в сыворотке крови выявила статистически значимое повышение показателей при СГХС относительно контрольной группы.  

Заключение

Заключение. Применение спекл-трекинг эхокардиографии позволило выявить среди детей с СГХС пациентов со снижением глобальной и сегментарной продольной деформации левого желудочка. 

Background. Familial hypercholesterolemia (FHC) is accompanied by a significant increase in the level of low-density lipoprotein cholesterol in the blood. The relevance of early diagnosis and treatment is due to the risk of premature development of atherosclerosis. Coronary heart disease due to atherosclerosis of the coronary arteries occurs among FHC patients up to 30 years. Currently, cardiac morphology and myocardial function in children with FHC are poorly understood. Objective. To assess global, segmental longitudinal deformation of the left ventricle and endothelial function in children with familial hypercholesterolemia. Design and methods. The study involved 25 healthy children and 34 children with FHC. Endothelin-1 and NO were determined by enzyme immunoassay. Echocardiographic study was carried. Assessment of global and segmental longitudinal deformation of the left ventricle was carried out in 4-chamber apical, 3-chamber and 2-chamber projections. Results. There were no statistically significant differences in global longitudinal strain (GLD) between groups. Individual analysis showed that 2 patients with FHC had a decrease in GLD. There was a statistically significant decrease in parameters in FHC patients at the level of the basal and apical anterior-septal, basal lower segments. Endothelin-1 and NO were increased in FHC compared to the control group. Conclusion. Speckle-tracking echocardiography allowed identifying patients with a decrease in global and segmental longitudinal deformation of the left ventricle among children with FHC. 

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Early myocardial deformation changes in hypercholesterolemic and obese children and adolescents: a 2D and 3D speckle tracking echocardiography study. Medicine (Baltimore). 2014; 93(12):e71. DOI: 10.1097/MD.0000000000000071.Vitarelli A, Martino F, Capotosto L, et al. Early myocardial deformation changes in hypercholesterolemic and obese children and adolescents: a 2D and 3D speckle tracking echocardiography study. Medicine (Baltimore). 2014; 93(12):e71. DOI: 10.1097/MD.0000000000000071.Lee TM, Chou TF, Tsai CH. Association of pravastatin and left ventricular mass in hypercholesterolemic patients: role of 8-iso-prostaglandin f2alpha formation. J Cardiovasc Pharmacol. 2002; 40(6):868–874. DOI: 10.1097/00005344-200212000-00007.Lee TM, Chou TF, Tsai CH. Association of pravastatin and left ventricular mass in hypercholesterolemic patients: role of 8-iso-prostaglandin f2alpha formation. J Cardiovasc Pharmacol. 2002; 40(6):868–874. DOI: 10.1097/00005344-200212000-00007.Rajapurohitam V, Javadov S, Purdham DM, et al. An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1. J Mol Cell Cardiol. 2006; 41(2):265–274. DOI: 10.1016/j. yjmcc.2006.05.001.Rajapurohitam V, Javadov S, Purdham DM, et al. An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1. J Mol Cell Cardiol. 2006; 41(2):265–274. DOI: 10.1016/j. yjmcc.2006.05.001.Chadjichristos CE, Matter CM, Roth I, et al. Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice. Circulation. 2006; 113(24):2835–2843. DOI: 10.1161/ CIRCULATIONAHA.106.627703.Chadjichristos CE, Matter CM, Roth I, et al. Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice. Circulation. 2006; 113(24):2835–2843. DOI: 10.1161/ CIRCULATIONAHA.106.627703.

The authors declare that there are no conflicts of interest present.