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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transmed</journal-id><journal-title-group><journal-title xml:lang="ru">Трансляционная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Translational Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-4495</issn><issn pub-type="epub">2410-5155</issn><publisher><publisher-name>Almazov National Medical Research Centre, Saint Petersburg, Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2311-4495-2021-8-2-37-45</article-id><article-id custom-type="elpub" pub-id-type="custom">transmed-606</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕДИАТРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PEDIATRICS</subject></subj-group></article-categories><title-group><article-title>Неврологический профиль детей низкого риска в возрасте 3–4 лет</article-title><trans-title-group xml:lang="en"><trans-title>Neurological profile of low-risk children at 3–4 years of age</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пальчик</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Palchik</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пальчик Александр Бейнусович, д.м.н., профессор кафедры неонатологии с курсами неврологии и акушерства-гинекологии ФП и ДПО; ведущий научный сотрудник НИЛ физиологии и патологии новорожденных  </p><p>ул. Литовская, д. 2, Санкт-Петербург, 194100</p></bio><bio xml:lang="en"><p>Palchik Aleksandr B., Dr. Sci., Professor of the Department of Neonatology with Courses in Neurology and Obstetrics-Gynecology, Researcher, Research Laboratory of Physiology and Pathology of Newborns </p><p>Litovskaya str., 2, Saint Petersburg, 194100 </p></bio><email xlink:type="simple">xander57@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пашков</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Pashkov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пашков Артем Юрьевич, врач-невролог отделения медицинской реабилитации </p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Pashkov Artem Yu., Neurologist, the Department of Medical Rehabilitation</p><p>Saint Petersburg</p></bio><email xlink:type="simple">pashkovay@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петрова Наталья Александровна, к.м.н., заведующий НИЛ физиологии и патологии новорожденных Института перинатологии и педиатрии </p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Petrova Natalia A., PhD, Head of the Research Laboratory of Physiology and Pathology of Newborns of the Institute of Perinatology and Pediatrics </p><p>Saint Petersburg</p></bio><email xlink:type="simple">petrova_na@almazovcentre.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Первунина</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Pervunina</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Первунина Татьяна Михайловна, д.м.н., директор Института перинатологии и педиатрии </p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Pervunina Tatyana Mikhailovna, Dr. Sci., Director of the Institute of Perinatology and Pediatrics </p><p>Saint Petersburg</p></bio><email xlink:type="simple">pervunina_tm@almazovcentre.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савельева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Savelyeva</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Савельева Наталья Александровна, к.м.н., ассистент кафедры неврологии и медицинской генетики </p><p>Пермь</p></bio><bio xml:lang="en"><p>Savelyeva Natalya A., PhD, Assistant Professor of the Department of Neurology and Medical Genetics </p><p>Perm</p></bio><email xlink:type="simple">natamed23@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg State Pediatric Medical University; Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Детский научно-клинический центр инфекционных болезней Федерального медико-биологического агентства»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Children’s Scientific and Clinical Center for Infectious Diseases of the Medical and Biological Federal Agency</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Пермский государственный медицинский университет имени академика Е. А. Вагнера»&#13;
Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Academician Ye. A. Vagner Perm State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>03</day><month>06</month><year>2021</year></pub-date><volume>8</volume><issue>2</issue><fpage>37</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пальчик А.Б., Пашков А.Ю., Петрова Н.А., Первунина Т.М., Савельева Н.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Пальчик А.Б., Пашков А.Ю., Петрова Н.А., Первунина Т.М., Савельева Н.А.</copyright-holder><copyright-holder xml:lang="en">Palchik A.B., Pashkov A.Y., Petrova N.A., Pervunina T.M., Savelyeva N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://transmed.almazovcentre.ru/jour/article/view/606">https://transmed.almazovcentre.ru/jour/article/view/606</self-uri><abstract><p>Актуальность. В дошкольном и школьном возрасте заболевания нервной системы и нарушения психомоторного развития встречаются приблизительно в 3 раза чаще, чем поражения нервной системы в период новорожденности. Для выяснения подобной динамики возникает необходимость стандартной неврологической оценки детей, находящихся в промежутке этих периодов, а именно в возрасте от 3 до 4 лет.Целью настоящего исследования послужила апробация методики стандартной неврологической оценки ребенка в возрасте около 3,5 лет.Материалы и методы. Проведено изучение особенностей неврологического статуса у 26 детей низкого риска в возрасте от 31 до 48 месяцев. Для решения поставленной задачи применен адаптированный стандартный неврологический профиль B. C. L.Touwen.Результаты. Показано, что у детей указанного возраста, признаваемых «неврологически здоровыми», отмечено не менее двух отклонений в неврологическом статусе от оптимальных значений. Наиболее частыми девиациями являются нарушения посадки из положения лежа на спине, снижение реакции на толчок сидя и изменения пассивного мышечного тонуса. Получен усредненный неврологический профиль для этих детей. Выявленные отклонения в неврологическом статусе коррелируют с нарушениями речевого развития (сроками формирования и объемом фразовой речи) (r = 0,69–0,74). Наряду с этим получена диссоциация между показателями отдельных неврологических функций и развития, что может свидетельствовать об индивидуальных траекториях развития. Заключение. Сопоставление неврологической заболеваемости в неонатальном периоде и в период раннего школьного возраста, имеющиеся данные о роли неврологических девиаций в возрасте около 3,5 лет с последующими когнитивными и поведенческими нарушениями, а также полученные результаты настоящего исследования о распространенности и характере индивидуальных отклонений у детей низкого риска позволяют предположить вероятный механизм роста неврологических, когнитивных и поведенческих расстройств у детей более позднего возраста.</p></abstract><trans-abstract xml:lang="en"><p>Background. Nervous system diseases and neurodevelopmental disorders are detected in children of preschool and school age approximately thrice as frequently as nervous system disorders in neonates. To investigate this dynamic, we admitted the necessity of standard neurological assessment of children in the interim period, that is at the age of 3–4 years old.Objective. The aim of the present research is practical testing of standard neurological assessment method for children at the approximate age of 3.5 years old.Design and methods. We studied neurological status characteristics in 26 low-risk children at the age 31–48 months with the adapted standard Neurological Profile of B. C. L. Touwen.Results. It is shown that in neurological status of children of the specified age, qualified as «neurologically healthy», not less than two deviations from optimal values were detected. The most common deviations were impaired sitting up from supine position, reduction of reaction to push in sitting position and passive muscle tone changes. The average neurological profile for these children was received. The detected neurological status deviations have correlation with speech development disorders (speech development milestones and phrase speech) (r = 0.69–0.74). At the same time, we noted dissociation between values of some neurological functions and development, and that may suggest individual of development.Conclusion. Comparison of neurological morbidity in neonatal period and in early preschool age, data about influence of neurological deviations at the approximate age of 3.5 years old on the future cognitive and behavioral disorders, as well as the findings obtained in the present research about prevalence and character of individual deviations in low-risk children, may suggest a probable mechanism of neurological, cognitive, and behavioral disorders increase in elder children.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>девиации</kwd><kwd>дети</kwd><kwd>индивидуальные траектории</kwd><kwd>неврологический профиль</kwd><kwd>оптимальность</kwd><kwd>развитие</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>development</kwd><kwd>deviations</kwd><kwd>individual trajectories</kwd><kwd>neurological profile</kwd><kwd>optimality</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование было выполнено при финансовой поддержке РФФИ в рамках научного проекта № 20-015-00269 и в рамках государственного задания № 075-00776-19-02.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Barashnev YuI, Burkova AS. 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