transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2015-0-1-52-56transmed-59Research ArticleАКУШЕРСТВО И ГИНЕКОЛОГИЯОбзор современных исследований по применению витамина D во время беременности и в послеродовом периодеШиринянЛариса Владиславовнаlarisadoc@mail.ruГуркинаЕлена Юрьевнаnoemail@neicon.ruЗазерскаяИрина Евгеньевнаnoemail@neicon.ruФГБУ «Северо-Западный федеральный медицинский исследовательский центр» Минздрава РоссииRussian Federation201523122016015256Copyright © Ширинян Л.В., Гуркина Е.Ю., Зазерская И.Е., 20162016Ширинян Л.В., Гуркина Е.Ю., Зазерская И.Е.Ширинян Л.В., Гуркина Е.Ю., Зазерская И.Е.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/59

В статье обсуждаются принятые в разных странах мира рекомендации к назначению препаратов витамина D во время беременности: минимальная потребность для беременных и кормящих женщин составляет 600 МЕ в день, однако для поддержания 25-(OH)D на достаточном уровне (т. е. выше 30 нг/мл) может потребоваться повышение ежедневной дозы до 1500-2000 МЕ. По данным исследования, проведенного в Санкт-Петербурге в 2013-2014 гг, через 20-25 недель от начала приема препаратов холекальциферола в группе беременных, получавших 500 МЕ витамина D, количество женщин с дефицитом уменьшилось почти вдвое. Применение витамина D в дозировке 1200 МЕ в течение месяца лишь на 6,8 ± 0,5 нг/мл увеличивало концентрацию 25-(OH)D в сыворотке крови и 25 % беременных даже на фоне приема витамина D имели его дефицит. Однако, назначение холекальциферола в суточной дозе 2000 МЕ в течение всей беременности показало более высокие уровни насыщения организма витамином D.

This article discusses the worldwide adopted recommendations for appointment of vitamin D during pregnancy: a minimal need for pregnant and lactating women is 600 IU per day, however, a daily dose may need to be increased to 1500-2000 IU to maintain a 25- (OH)D at a sufficient level (i. e. above 30 ng/ml). According to a study carried out in St. Petersburg in 2013-2014 years, after 20-25 weeks from the beginning of cholecalciferol supplementation in a group of pregnant women who received 500 IU of vitamin D, the number of women with a deficit almost halved. Applying vitamin D 1200 IU per dose for one month increased the concentration of 25- (OH)D in the blood serum by only 6,8 ± 0,5 ng/ml, and 25 % of pregnant women had a vitamin D deficiency even receiving it. However, the appointment of a daily dose of cholecalciferol 2000 IU during pregnancy showed higher levels of saturation of the body with vitamin D.

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The authors declare that there are no conflicts of interest present.