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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transmed</journal-id><journal-title-group><journal-title xml:lang="ru">Трансляционная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Translational Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-4495</issn><issn pub-type="epub">2410-5155</issn><publisher><publisher-name>Almazov National Medical Research Centre, Saint Petersburg, Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2311-4495-2020-7-5-62-80</article-id><article-id custom-type="elpub" pub-id-type="custom">transmed-585</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭНДОКРИНОЛОГИЧЕСКИЕ ЗАБОЛЕВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METABOLIC DISEASES</subject></subj-group></article-categories><title-group><article-title>Современная концепция нейроэндокринной и эпигенетической регуляции старта пубертата и полового развития. Трансляционные исследования роли лиганд-рецепторной системы кисспептина KISS/KISS1R</article-title><trans-title-group xml:lang="en"><trans-title>Modern concept of neuroendocrine and epigenetic regulation of the onset of puberty and sexual development. Translational studies on the role of the KISS/KISS1R system</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитина</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitina</surname><given-names>I. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никитина Ирина Леоровна, д.м.н., заведующий НИЛ детской эндокринологии Института эндокринологии, заведующий кафедрой детских болезней Института медицинского образования</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Nikitina Irina L., MD, PhD, Head of Research Laboratory of Pediatric Endocrinology at Institute of Endocrinology, Head of the Department of Childhood Diseases, Institute of Medical Education</p><p>Akkuratova str. 2, Saint Petersburg, 197341</p></bio><email xlink:type="simple">nikitina0901@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юхлина</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Yuchlina</surname><given-names>Y. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юхлина Юлия Николаевна, ассистент кафедры детских болезней Института медицинского образования</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Yuchlina Yulia N., Assistant at the Department of Childhood Diseases, Institute of Medical Education</p><p>Saint Petersburg</p></bio><email xlink:type="simple">dom-j@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саракаева</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sarakaeva</surname><given-names>L. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Саракаева Лейла Рамазановна, младший научный сотрудник НИЛ детской эндокринологии Института эндокринологии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Sarakaeva Leyla R., Junior Researcher at Research Laboratory of Pediatric Endocrinology at Institute of Endocrinology</p><p>Saint Petersburg</p></bio><email xlink:type="simple">sarale723@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плаксина</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Plaksina</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плаксина Анна Олеговна, старший лаборант кафедры детских болезней Института медицинского образования</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Plaksina Anna O., Senior Laboratory Assistant, Department of Childhood Diseases, Institute of Medical Education</p><p>Saint Petersburg</p></bio><email xlink:type="simple">plananyuta@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Байрамов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bayramov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Байрамов Алекбер Азизович, д.м.н., ведущий научный сотрудник НИЛ клинической эндокринологии Института эндокринологии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Bayramov Alekber A., MD, PhD, Leading Researcher, Research Laboratory of Clinical Endocrinology, Institute of Endocrinology</p><p>Saint Petersburg</p></bio><email xlink:type="simple">alekber@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>12</day><month>10</month><year>2020</year></pub-date><volume>7</volume><issue>5</issue><fpage>62</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Никитина И.Л., Юхлина Ю.Н., Саракаева Л.Р., Плаксина А.О., Байрамов А.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Никитина И.Л., Юхлина Ю.Н., Саракаева Л.Р., Плаксина А.О., Байрамов А.А.</copyright-holder><copyright-holder xml:lang="en">Nikitina I.L., Yuchlina Y.N., Sarakaeva L.R., Plaksina A.O., Bayramov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://transmed.almazovcentre.ru/jour/article/view/585">https://transmed.almazovcentre.ru/jour/article/view/585</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>гипогонадизм</kwd><kwd>гонадотропин-рилизинг гормон</kwd><kwd>кисспептин</kwd><kwd>мальчики</kwd><kwd>пубертат</kwd><kwd>тестостерон</kwd></kwd-group><kwd-group xml:lang="en"><kwd>boys</kwd><kwd>gonadotropin-releasing hormone</kwd><kwd>hypogonadism</kwd><kwd>kisspeptin</kwd><kwd>puberty</kwd><kwd>testosterone</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Abreu AP, Kaiser UB. 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