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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transmed</journal-id><journal-title-group><journal-title xml:lang="ru">Трансляционная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Translational Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-4495</issn><issn pub-type="epub">2410-5155</issn><publisher><publisher-name>Almazov National Medical Research Centre, Saint Petersburg, Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2311-4495-2020-7-1-39-52</article-id><article-id custom-type="elpub" pub-id-type="custom">transmed-538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АНЕСТЕЗИОЛОГИЯ И РЕАНИМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PAIN, CRITICAL CARE, AND ANESTHESIA</subject></subj-group></article-categories><title-group><article-title>Пропорциональная вспомогательная вентиляция</article-title><trans-title-group xml:lang="en"><trans-title>Proportional assist ventilation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазурок</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mazurok</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мазурок Вадим Альбертович, д.м.н., профессор, заведующий кафедрой анестезиологии и реаниматологии Института медицинского образования</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341</p></bio><bio xml:lang="en"><p>Mazurok Vadim A., MD, PhD, Dr. Sc., Professor and Chairman Department of Anaesthesiology/Reanimatology, Institute of Medical Education</p><p>Akkuratova str. 2, Saint Petersburg, Russia, 197341</p></bio><email xlink:type="simple">vmazurok@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>10</day><month>03</month><year>2020</year></pub-date><volume>7</volume><issue>1</issue><fpage>39</fpage><lpage>52</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мазурок В.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Мазурок В.А.</copyright-holder><copyright-holder xml:lang="en">Mazurok V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://transmed.almazovcentre.ru/jour/article/view/538">https://transmed.almazovcentre.ru/jour/article/view/538</self-uri><abstract><p>Идея пропорциональной вспомогательной вентиляции легких, при которой респираторный паттерн — частоту и глубину дыхания — задает сам пациент, была высказана в 1992 году, однако до сих не нашла широкого практического применения. Одной из возможных причин тому является сложный алгоритм настройки режима на респираторах первых поколений. Со временем накопленный массив информации о раннем поражении диафрагмы в результате ее атрофии у пациентов, находящихся на респираторной поддержке, лег в основу осознания важности поддержания физиологического состояния диафрагмы во время искусственной вентиляции легких и обусловил появление термина «миотравма». На рубеже XXI века идея максимально возможного сохранения самостоятельного дыхания у пациента во время проведения механической вентиляции легких реализовалась в формировании концепции «диафрагма-протективной вентиляции». Стала очевидной необходимость дальнейшего развития технологий вспомогательной вентиляции легких, призванных уменьшить риск повреждения диафрагмы, снизить частоту асинхронии в паре «пациент–респиратор», облегчить процесс отлучения пациента от аппарата искусственной вентиляции легких. Настоящая статья, основанная на данных литературы и собственном клиническом опыте использования пропорциональной вентиляции, описывает особенности настройки режима на разных респираторах, расставляет акценты, необходимые для успешного клинического использования пропорциональной вентиляции легких. Описывает условия ее проведения, преимущества и ограничения.</p></abstract><trans-abstract xml:lang="en"><p>The idea of proportional assist ventilation, in which the patient himself sets the respiratory pattern — the frequency and depth of breathing — was suggested in 1992, but has not yet found widespread practical application. One of the possible reasons for this is the complex algorithm of regime adjustment on first-generation respiratory devices. Over time, the accumulated body of information on the early damage of the diaphragm because of its atrophy in patients on respiratory support formed the basis of the awareness of the importance of maintaining the physiological state of the diaphragm during artificial lung ventilation and led to the emergence of the term “myotrauma”.</p><p>At the turn the 21st century, the idea of the maximum possible preservation of spontaneous breathing of the patient during mechanical lung ventilation realized in the formation of the concept of “diaphragm-protective ventilation”. The need for further development of assisted lung ventilation technologies designed to reduce the risk of diaphragm damage, the frequency of asynchrony in the pair “respirator-patient”, and to facilitate the process of weaning of the patient from the artificial lung ventilation became apparent. This article, based on scientific literature and own clinical experience of using proportional ventilation, describes the peculiarities of regime adjustment on different respirators, places the accents necessary for successful practical use of proportional lung ventilation. Describes key conditions for its use, advantages and limitations.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пропорциональная вентиляция</kwd><kwd>работа дыхания</kwd><kwd>диафрагма-протективная</kwd></kwd-group><kwd-group xml:lang="en"><kwd>proportional ventilation</kwd><kwd>work of breathing</kwd><kwd>diaphragm-protective</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Маша и медведь / В обраб. М.А. Булатова. Мо- сква: Детгиз, 1960.</mixed-citation><mixed-citation xml:lang="en">Маша и медведь / В обраб. М.А. Булатова. Мо- сква: Детгиз, 1960.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Schepens T, Dres M, Heunks L et al. Diaphragmprotective mechanical ventilation. Curr Opin Crit Care. 2019;25(1):77–85.</mixed-citation><mixed-citation xml:lang="en">Schepens T, Dres M, Heunks L et al. Diaphragmprotective mechanical ventilation. Curr Opin Crit Care. 2019;25(1):77–85.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Decavèle M, Similowski T, Demoule A. Detection and management of dyspnea in mechanically ventilated patients. Curr Opin Crit Care. 2019;25(1):86–94.</mixed-citation><mixed-citation xml:lang="en">Decavèle M, Similowski T, Demoule A. Detection and management of dyspnea in mechanically ventilated patients. Curr Opin Crit Care. 2019;25(1):86–94.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Goligher EC, Dres M, Fan E et al. Mechanical ventilation-induced diaphragm atrophy strongly impacts clinical outcomes. Am J Respir Crit Care Med. 2018;197(2):204–213.</mixed-citation><mixed-citation xml:lang="en">Goligher EC, Dres M, Fan E et al. Mechanical ventilation-induced diaphragm atrophy strongly impacts clinical outcomes. Am J Respir Crit Care Med. 2018;197(2):204–213.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Demoule A, Jung B, Prodanovic H et al. Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study. Am J Respir Crit Care Med. 2013;188(2):213–219.</mixed-citation><mixed-citation xml:lang="en">Demoule A, Jung B, Prodanovic H et al. Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study. Am J Respir Crit Care Med. 2013;188(2):213–219.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Younes M. Proportional assist ventilation, a new approach to ventilatory support. Theory. Am Rev Respir Dis. 1992;145(1):114–120.</mixed-citation><mixed-citation xml:lang="en">Younes M. Proportional assist ventilation, a new approach to ventilatory support. Theory. Am Rev Respir Dis. 1992;145(1):114–120.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Georgopoulos D, Xirouchaki N, Tzanakis N et al. Data on respiratory variables in critically ill patients with acute respiratory failure placed on proportional assist ventilation with load adjustable gain factors (PAV+). Data Brief. 2016;8:484–493.</mixed-citation><mixed-citation xml:lang="en">Georgopoulos D, Xirouchaki N, Tzanakis N et al. Data on respiratory variables in critically ill patients with acute respiratory failure placed on proportional assist ventilation with load adjustable gain factors (PAV+). Data Brief. 2016;8:484–493.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Georgopoulos D, Xirouchaki N, Tzanakis N et al. Driving pressure during assisted mechanical ventilation: Is it controlled by patient brain? Respir Physiol Neurobiol. 2016;228:69–75.</mixed-citation><mixed-citation xml:lang="en">Georgopoulos D, Xirouchaki N, Tzanakis N et al. Driving pressure during assisted mechanical ventilation: Is it controlled by patient brain? Respir Physiol Neurobiol. 2016;228:69–75.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Vaporidi K, Psarologakis C, Proklou A et al. Driving pressure during proportional assist ventilation: an observational study. Ann Intensive Care. 2019;9(1):1.</mixed-citation><mixed-citation xml:lang="en">Vaporidi K, Psarologakis C, Proklou A et al. Driving pressure during proportional assist ventilation: an observational study. Ann Intensive Care. 2019;9(1):1.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Su PL, Kao PS, Lin WC et al. Limited predictability of maximal muscular pressure using the difference between peak airway pressure and positive end-expiratory pressure during proportional assist ventilation (PAV). Crit Care. 2016;20(1):382.</mixed-citation><mixed-citation xml:lang="en">Su PL, Kao PS, Lin WC et al. Limited predictability of maximal muscular pressure using the difference between peak airway pressure and positive end-expiratory pressure during proportional assist ventilation (PAV). Crit Care. 2016;20(1):382.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Alexopoulou C, Kondili E, Plataki M et al. Patientventilator synchrony and sleep quality with proportional assist and pressure support ventilation. Intensive Care Med. 2013;39(6):1040–1047.</mixed-citation><mixed-citation xml:lang="en">Alexopoulou C, Kondili E, Plataki M et al. Patientventilator synchrony and sleep quality with proportional assist and pressure support ventilation. Intensive Care Med. 2013;39(6):1040–1047.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bosma KJ, Read BA, Bahrgard Nikoo MJ et al. A pilot randomized trial comparing weaning from mechanical ventilation on pressure support versus proportional assist ventilation. Crit Care Med. 2016;44(6):1098–1108.</mixed-citation><mixed-citation xml:lang="en">Bosma KJ, Read BA, Bahrgard Nikoo MJ et al. A pilot randomized trial comparing weaning from mechanical ventilation on pressure support versus proportional assist ventilation. Crit Care Med. 2016;44(6):1098–1108.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Costa R, Spinazzola G, Cipriani F et al. A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV). Intensive Care Med. 2011;37(9):1494–1500.</mixed-citation><mixed-citation xml:lang="en">Costa R, Spinazzola G, Cipriani F et al. A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV). Intensive Care Med. 2011;37(9):1494–1500.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Costa R, Navalesi P, Spinazzola G, et al. Comparative evaluation of different helmets on patient-ventilator interaction during noninvasive ventilation. Intensive Care Med. 2008; Intensive Care Med. 2008; 34(6):1102–1108.</mixed-citation><mixed-citation xml:lang="en">Costa R, Navalesi P, Spinazzola G, et al. Comparative evaluation of different helmets on patient-ventilator interaction during noninvasive ventilation. Intensive Care Med. 2008; Intensive Care Med. 2008; 34(6):1102–1108.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Elganady AA, Beshey BN, Abdelasis AAH. Proportional assist ventilation versus pressure support ventilation in the weaning of patients with acute exacerbation of chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberc. 2014;63(3):643–650.</mixed-citation><mixed-citation xml:lang="en">Elganady AA, Beshey BN, Abdelasis AAH. Proportional assist ventilation versus pressure support ventilation in the weaning of patients with acute exacerbation of chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberc. 2014;63(3):643–650.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hergott CA, Bosma KJ, Ferreyra G et al. Effect of patient-ventilator asynchrony on arousals from sleep during pressure support and proportional assist mechanical ventilation. Chest. 2008;134: s18001–s18001.</mixed-citation><mixed-citation xml:lang="en">Hergott CA, Bosma KJ, Ferreyra G et al. Effect of patient-ventilator asynchrony on arousals from sleep during pressure support and proportional assist mechanical ventilation. Chest. 2008;134: s18001–s18001.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hosking B, Nikoo M, Bosma KJ. The incidence of patient-ventilator asynchrony during weaning from mechanical ventilation: a comparison of proportional assist ventilation (PAV) to pressure support (PS). Am J Respir Crit Care Med. 2011;183:A3197.</mixed-citation><mixed-citation xml:lang="en">Hosking B, Nikoo M, Bosma KJ. The incidence of patient-ventilator asynchrony during weaning from mechanical ventilation: a comparison of proportional assist ventilation (PAV) to pressure support (PS). Am J Respir Crit Care Med. 2011;183:A3197.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt M, Kindler F, Cecchini J et al. Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator interaction. Crit Care. 2015;19:56.</mixed-citation><mixed-citation xml:lang="en">Schmidt M, Kindler F, Cecchini J et al. Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator interaction. Crit Care. 2015;19:56.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Vasconcelos RS, Sales RP, Melo LHP et al. Influences of duration of inspiratory effort, respiratory mechanics, and ventilator type on asynchrony with pressure support and proportional assist ventilation. Respir Care. 2017;62(5):550–557.</mixed-citation><mixed-citation xml:lang="en">Vasconcelos RS, Sales RP, Melo LHP et al. Influences of duration of inspiratory effort, respiratory mechanics, and ventilator type on asynchrony with pressure support and proportional assist ventilation. Respir Care. 2017;62(5):550–557.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Xirouchaki N, Kondili E, Vaporidi K et al. Proportional assist ventilation with load-adjustable gain factors in critically ill patients: comparison with pressure support. Intensive Care Med. 2008;34(11):2026–2034.</mixed-citation><mixed-citation xml:lang="en">Xirouchaki N, Kondili E, Vaporidi K et al. Proportional assist ventilation with load-adjustable gain factors in critically ill patients: comparison with pressure support. Intensive Care Med. 2008;34(11):2026–2034.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Younes M, Brochard L, Grasso S et al. A method for monitoring and improving patient: ventilator interaction. Intensive Care Med. 2007;33(8):1337–1146.</mixed-citation><mixed-citation xml:lang="en">Younes M, Brochard L, Grasso S et al. A method for monitoring and improving patient: ventilator interaction. Intensive Care Med. 2007;33(8):1337–1146.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Iammes Y, Auran Y, Gouvernet J et al. The ventilatory pattern of conscious man according to age and morphology. Bull Eur Physiopathol Respir. 1979;15:527–540.</mixed-citation><mixed-citation xml:lang="en">Iammes Y, Auran Y, Gouvernet J et al. The ventilatory pattern of conscious man according to age and morphology. Bull Eur Physiopathol Respir. 1979;15:527–540.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Marantz S, Patrick W, Webster K et al. Response of ventilator-dependent patients to different levels of proportional assist. J Appl Physiol. 1996:80(2):397–403.</mixed-citation><mixed-citation xml:lang="en">Marantz S, Patrick W, Webster K et al. Response of ventilator-dependent patients to different levels of proportional assist. J Appl Physiol. 1996:80(2):397–403.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Giannouli E, Webster K, Roberts D et al. Response of ventilator-dependent patients to different levels of pressure support and proportional assist. Am J Respir Crit Care Med. 1999;159(6):1716–1725.</mixed-citation><mixed-citation xml:lang="en">Giannouli E, Webster K, Roberts D et al. Response of ventilator-dependent patients to different levels of pressure support and proportional assist. Am J Respir Crit Care Med. 1999;159(6):1716–1725.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Puddy A, Patrick W, Webster K et al. Respiratory control during volume-cycled ventilation in normal humans. J Appl Physiol. 1996;80(5):1749–1758.</mixed-citation><mixed-citation xml:lang="en">Puddy A, Patrick W, Webster K et al. Respiratory control during volume-cycled ventilation in normal humans. J Appl Physiol. 1996;80(5):1749–1758.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Seymour CW, Pandharipande PP, Koestner T et al. Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Crit Care Med. 2012;40(10):2788–2796.</mixed-citation><mixed-citation xml:lang="en">Seymour CW, Pandharipande PP, Koestner T et al. Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Crit Care Med. 2012;40(10):2788–2796.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Lipshutz AK, Gropper MA. Acquired neuromuscular weakness and early mobilization in the intensive care unit. Anesthesiology. 2013;118(1):202–215.</mixed-citation><mixed-citation xml:lang="en">Lipshutz AK, Gropper MA. Acquired neuromuscular weakness and early mobilization in the intensive care unit. Anesthesiology. 2013;118(1):202–215.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kallet RH, Campbell AR, Dicker RA et al. Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med. 2006;34(1):8–14.</mixed-citation><mixed-citation xml:lang="en">Kallet RH, Campbell AR, Dicker RA et al. Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med. 2006;34(1):8–14.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kallet RH, Corral W, Silverman HJ et al. Implementation of a low tidal volume ventilation protocol for patients with acute lung injury or acute respiratory distress syndrome. Respir Care. 2001;46(10):1024–1037.</mixed-citation><mixed-citation xml:lang="en">Kallet RH, Corral W, Silverman HJ et al. Implementation of a low tidal volume ventilation protocol for patients with acute lung injury or acute respiratory distress syndrome. Respir Care. 2001;46(10):1024–1037.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Brander L, Sinderby C, Lecomte F et al. Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury. Intensive Care Med. 2009;35(11):1979–1989.</mixed-citation><mixed-citation xml:lang="en">Brander L, Sinderby C, Lecomte F et al. Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury. Intensive Care Med. 2009;35(11):1979–1989.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Akoumianaki E, Prinianakis G1, Kondili E et al. Physiologic comparison of neurally adjusted ventilator assist, proportional assist and pressure support ventilation in critically ill patients. Respir Physiol Neurobiol. 2014;203:82–89.</mixed-citation><mixed-citation xml:lang="en">Akoumianaki E, Prinianakis G1, Kondili E et al. Physiologic comparison of neurally adjusted ventilator assist, proportional assist and pressure support ventilation in critically ill patients. Respir Physiol Neurobiol. 2014;203:82–89.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kondili E, Prinianakis G, Alexopoulou C et al. Respiratory load compensation during mechanical ventilation-proportional assist ventilation with loadadjustable gain factors versus pressure support. Intensive Care Med. 2006;32(5):692–699.</mixed-citation><mixed-citation xml:lang="en">Kondili E, Prinianakis G, Alexopoulou C et al. Respiratory load compensation during mechanical ventilation-proportional assist ventilation with loadadjustable gain factors versus pressure support. Intensive Care Med. 2006;32(5):692–699.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ruiz-Ferrón F, Machado J, Morante A et al. Respiratory work and pattern with different proportional assist ventilation levels. Med Intensiva. 2009;33(6):269–275.</mixed-citation><mixed-citation xml:lang="en">Ruiz-Ferrón F, Machado J, Morante A et al. Respiratory work and pattern with different proportional assist ventilation levels. Med Intensiva. 2009;33(6):269–275.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Alexopoulou C, Kondili E, Vakouti E et al. Sleep during proportional-assist ventilation with load-adjustable gain factors in critically ill patients. Intensive Care Med. 2007;33(7):1139–1147.</mixed-citation><mixed-citation xml:lang="en">Alexopoulou C, Kondili E, Vakouti E et al. Sleep during proportional-assist ventilation with load-adjustable gain factors in critically ill patients. Intensive Care Med. 2007;33(7):1139–1147.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sinderby C, Beck J. Proportional assist ventilation and neurally adjusted ventilatory assist-better approaches to patient ventilator synchrony? Clin Chest Med. 2008;29(2):329–342.</mixed-citation><mixed-citation xml:lang="en">Sinderby C, Beck J. Proportional assist ventilation and neurally adjusted ventilatory assist-better approaches to patient ventilator synchrony? Clin Chest Med. 2008;29(2):329–342.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Stein H, Firestone K, Rimensberger PC. Synchronized mechanical ventilation using electrical activity of the diaphragm in neonates. Clin Perinatol. 2012;39(3):525–542.</mixed-citation><mixed-citation xml:lang="en">Stein H, Firestone K, Rimensberger PC. Synchronized mechanical ventilation using electrical activity of the diaphragm in neonates. Clin Perinatol. 2012;39(3):525–542.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Colombo D, Cammarota G, Bergamaschi V et al. Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute 2018.</mixed-citation><mixed-citation xml:lang="en">Colombo D, Cammarota G, Bergamaschi V et al. Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute 2018.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Moerer O, Beck J, Brander L et al. Subjectventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation. Intensive Care Med. 2008;34(9):1615–1623.</mixed-citation><mixed-citation xml:lang="en">Moerer O, Beck J, Brander L et al. Subjectventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation. Intensive Care Med. 2008;34(9):1615–1623.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Beck J, Gottfried SB, Navalesi P et al. Electrical activity of the diaphragm during pressure support ventilation in acute respiratory failure. Am J Respir Crit Care Med. 2001;164(3):419–424.</mixed-citation><mixed-citation xml:lang="en">Beck J, Gottfried SB, Navalesi P et al. Electrical activity of the diaphragm during pressure support ventilation in acute respiratory failure. Am J Respir Crit Care Med. 2001;164(3):419–424.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Mitrouska J, Xirouchaki N, Patakas D et al. Effects of chemical feedback on respiratory motor and ventilatory output during different modes of assisted mechanical ventilation. Eur Respir J. 1999;13(4):873–882.</mixed-citation><mixed-citation xml:lang="en">Mitrouska J, Xirouchaki N, Patakas D et al. Effects of chemical feedback on respiratory motor and ventilatory output during different modes of assisted mechanical ventilation. Eur Respir J. 1999;13(4):873–882.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Nava S, Bruschi C, Fracchia C et al. Patientventilator interaction and inspiratory effort during pressure support ventilation in patients with different pathologies. Eur Respir J. 1997;10(1):177–183.</mixed-citation><mixed-citation xml:lang="en">Nava S, Bruschi C, Fracchia C et al. Patientventilator interaction and inspiratory effort during pressure support ventilation in patients with different pathologies. Eur Respir J. 1997;10(1):177–183.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Beck J, Sinderby C, Lindström L et al. Diaphragm interference pattern EMG and compound muscle action potentials: effects of chest wall configuration. J Appl Physiol. 1997;82(2):520–530.</mixed-citation><mixed-citation xml:lang="en">Beck J, Sinderby C, Lindström L et al. Diaphragm interference pattern EMG and compound muscle action potentials: effects of chest wall configuration. J Appl Physiol. 1997;82(2):520–530.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Sinderby CA, Beck JC, Lindström LH et al. Enhancement of signal quality in esophageal recordings of diaphragm EMG. J Appl Physiol. 1997;82(4):1370–1377.</mixed-citation><mixed-citation xml:lang="en">Sinderby CA, Beck JC, Lindström LH et al. Enhancement of signal quality in esophageal recordings of diaphragm EMG. J Appl Physiol. 1997;82(4):1370–1377.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Fabry B, Guttmann J, Eberhard L et al. An analysis of desynchronization between the spontaneously breathing patient and ventilator during inspiratory pressure support. Chest. 1995;107(5):1387–1394.</mixed-citation><mixed-citation xml:lang="en">Fabry B, Guttmann J, Eberhard L et al. An analysis of desynchronization between the spontaneously breathing patient and ventilator during inspiratory pressure support. Chest. 1995;107(5):1387–1394.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sinderby C, Beck J, Spahija J et al. Voluntary activation of the human diaphragm in health and disease. J Appl Physiol. 1998;85(6):2146–2158.</mixed-citation><mixed-citation xml:lang="en">Sinderby C, Beck J, Spahija J et al. Voluntary activation of the human diaphragm in health and disease. J Appl Physiol. 1998;85(6):2146–2158.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Sinderby C, Beck J, Spahija J et al. Inspiratory muscle unloading by neurally adjusted ventilatory assist during maximal inspiratory efforts in healthy subjects. Chest. 2007;131(3):711–717.</mixed-citation><mixed-citation xml:lang="en">Sinderby C, Beck J, Spahija J et al. Inspiratory muscle unloading by neurally adjusted ventilatory assist during maximal inspiratory efforts in healthy subjects. Chest. 2007;131(3):711–717.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Sinderby C, Spahija J, Beck J et al. Diaphragm activation during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163(7):1637–1641.</mixed-citation><mixed-citation xml:lang="en">Sinderby C, Spahija J, Beck J et al. Diaphragm activation during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163(7):1637–1641.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
