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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transmed</journal-id><journal-title-group><journal-title xml:lang="ru">Трансляционная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Translational Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-4495</issn><issn pub-type="epub">2410-5155</issn><publisher><publisher-name>Almazov National Medical Research Centre, Saint Petersburg, Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2311-4495-2014-0-4-5-10</article-id><article-id custom-type="elpub" pub-id-type="custom">transmed-44</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭНДОКРИНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ENDOCRINOLOGY</subject></subj-group></article-categories><title-group><article-title>Новые технологии в профилактике и лечении сахарного диабета 1 типа</article-title><trans-title-group xml:lang="en"><trans-title>NEW TECHNOLOGIES IN PREVENTION AND TREATMENT OF DIABETES TYPE 1</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гринёва</surname><given-names>Елена Николаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Grineva</surname><given-names>E. N.</given-names></name></name-alternatives><email xlink:type="simple">grineva_e@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кравчук</surname><given-names>Екатерина Никодимовна</given-names></name><name name-style="western" xml:lang="en"><surname>Kravchuk</surname><given-names>E. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Федеральный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Almazov Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>4</issue><fpage>5</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гринёва Е.Н., Кравчук Е.Н., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Гринёва Е.Н., Кравчук Е.Н.</copyright-holder><copyright-holder xml:lang="en">Grineva E.N., Kravchuk E.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://transmed.almazovcentre.ru/jour/article/view/44">https://transmed.almazovcentre.ru/jour/article/view/44</self-uri><abstract><p>Сахарный диабет 1А типа (СД1) является аутоиммунным заболеванием, характеризующимся деструкцией бета-клеток с развитием абсолютной инсулиновой недостаточности. Единственным эффективным способом терапии СД1 в настоящий момент является пожизненная заместительная инсулинотерапия. К сожалению, успешных методов профилактики и лечения СД1 в настоящий момент не существует. В данном обзоре будут рассмотрены результаты наиболее современных исследований по первичной, вторичной и третичной профилактике СД1.</p></abstract><trans-abstract xml:lang="en"><p>Diabetes mellitus type 1 (DM1) is an autoimmune disease with beta-cell destruction and absolute insulin deficiency. The most effective therapy of DM1 is lifelong vicarous insulinterapy. Unfortunately, there is no successful methods of prophylaxis and treatment of DM1. In this review we will discuss results of modern trials of primary, secondary and tertiary prophylaxis of DM1.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет</kwd><kwd>профилактика</kwd><kwd>бета-клетка</kwd><kwd>инсулин</kwd><kwd>diabetes mellitus</kwd><kwd>prevention</kwd><kwd>beta-cell</kwd><kwd>insulin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Yoon J.W., Jun H.S. Cellular and molecular pathogenic mechanisms of insulin-dependent diabetes mellitus / Ann. N.Y. Acad Sci. - 2001. - Vol. 928. - P. 200-211.</mixed-citation><mixed-citation xml:lang="en">Yoon J.W., Jun H.S. Cellular and molecular pathogenic mechanisms of insulin-dependent diabetes mellitus / Ann. N.Y. 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