transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2018-5-3-45-65transmed-437Research ArticleОНКОЛОГИЯМетоды подбора in vitro химиопрепаратов для индивидуальной химиотерапии злокачественных новообразований пациентовThe methods of in vitro selection of chemotherapeutic druds for individual chemotherapy of maligant tumors in patinetsЧерновА. Н.ChernovA. N.

Чернов Александр Николаевич - научный сотрудник отдела микробиологии, клеточных технологий и молекулярной биологии Центра доклинических и трансляционный исследований Института экспериментальной медицины.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Aleksandr N. Chernov - researcher, the department of microbiology.

Akkuratova str. 2, Saint Petersburg, 197341

al.chernov@mail.ruБаранцевичЕ. П.BarantsevichE. P.

Баранцевич Елена Петровна - доктор медицинских наук, заведующая НИО микробиологии.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Elena P. Barantsevich - Dr. Sci., head of the department of microbiology.

Akkuratova str. 2, Saint Petersburg, 197341

КалюновВ. Н.KalunovV. N.

Калюнов Владимир Николаевич – доктор биологических наук, профессор, главный научный сотрудник лаборатории нейрофизиологии.

Минск

Vladimir N. Kalunov - Dr. Sci.,Prof., leading researcher, laboratory of neurophysiology, Institute of Physiology.

Minsk

ГалагудзаМ. М.GalagudzaM. M.

Галагудза Михаил Михайлович - доктор медицинских наук, член-корреспондент РАН, директор Института экспериментальной медицины.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Mikhail M. Galagudza - Dr. Sci., Prof., head of the Experimental medicine Institute.

Akkuratova str. 2, Saint Petersburg, 197341

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава РоссииРоссияAlmazov National Medical Research CentreRussian FederationГНУ Институт физиологии НАН БеларусиБеларусьInstitute of Physiology of the National Academy of Sciences of BelarusBelarus201801102018534565Copyright © Чернов А.Н., Баранцевич Е.П., Калюнов В.Н., Галагудза М.М., 20182018Чернов А.Н., Баранцевич Е.П., Калюнов В.Н., Галагудза М.М.Chernov A.N., Barantsevich E.P., Kalunov V.N., Galagudza M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/437

В обзоре рассматриваются методы подбора химио- и биопрепаратов, их комбинаций с использованием 2D и 3D моделей культур клеток для прогнозирования персонифицированного ответа пациентов со злокачественными новообразованиями (рак яичников, желудка, кишечника, легкого, молочной, поджелудочной желез, опухоли головы и шеи) на химиотерапию. Приводятся показатели эффективности (чувствительность, специфичность, пролонгирование общей и безрецидивной выживаемости) методов оценки химиочувствительности на культурах опухолевых клеток при сравнении их с эффективностью химиотерапии пациентов. В статье освещаются преимущества и недостатки описываемых методов и перспективы их дальнейшего применения в клинической практике.

The review considers methods for selecting chemo- and biopreparations, their combinations using 2D and 3D cell culture models to predict a personified response of patients with malignant neoplasms (ovarian, stomach, intestine, lung, lacteal, pancreas, head and neck cancer) to chemotherapy. Performance indicators (sensitivity, specificity, prolongation of total and disease-free survival) of chemosensitivity assessment methods in cultures of tumor cells are analyzed on the basis of their comparison with the effectiveness of chemotherapy of patients. The article highlights the advantages and disadvantages of the methods described, the prospects for their further application in clinical practice.

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The authors declare that there are no conflicts of interest present.