transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2018-5-3-36-44transmed-436Research ArticleНЕВРОЛОГИЯ И НЕЙРОХИРУРГИЯNEUROLOGY AND NEUROSURGERYНегенетические экспериментальные модели эпилепсии in vivo и стимуляция блуждающего нерваNon-genetic in vivo experimental models of epilepsy and vagus nerve stimulationМалышевС. М.MalyshevS. M.

Малышев Станислав Михайлович - аспирант, кафедра неврологии и психиатрии, Институт медицинского образования.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Stanislav M. Malyshev - MD, postgraduate student, Department of Neurology and Psychiatry, Institute of Medical Education.

Akkuratova str. 2, Saint Petersburg, 197341

malyshev_sm@almazovcentre.ruАлексееваТ. М.AlekseevaT. M.

Алексеева Татьяна Михайловна - доктор медицинских наук, заведующая кафедрой неврологии и психиатрии, Институт медицинского образования.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Tatiana M. Alekseeva - MD, PhD, the Head of the Department of Neurology and Psychiatry, Institute of Medical Educatio.

Akkuratova str. 2, Saint Petersburg, 197341

ХачатрянВ. А.KhachatryanW. A.

Хачатрян Вильям Арамович - доктор медицинских наук, профессор, заведующий отделением нейрохирургии детского возраста.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

William A. Khachatryan - MD, PhD, Professor, the Head of the Department of Pediatric Neurosurgery.

Akkuratova str. 2, Saint Petersburg, 197341

ГалагудзаМ. М.GalagudzaM. M.

Галагудза Михаил Михайлович - доктор медицинских наук, профессор, чл.корр. РАН, директор Института экспериментальной медицины.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Mikhail M. Galagudza - MD, PhD, Professor, Associate of the Russian Academy of Science, the Head of the Institute of Experimental Medicine.

Akkuratova str. 2, Saint Petersburg, 197341

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава РоссииРоссияAlmazov National Medical Research CentreRussian Federation201801102018533644Copyright © Малышев С.М., Алексеева Т.М., Хачатрян В.А., Галагудза М.М., 20182018Малышев С.М., Алексеева Т.М., Хачатрян В.А., Галагудза М.М.Malyshev S.M., Alekseeva T.M., Khachatryan W.A., Galagudza M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/436

Сложность эпилепсии и эпилептического приступа как клинических и патофизиологических понятий находит своё отражение в большом числе предложенных экспериментальных моделей эпилепсии. Их можно разделить на острые и хронические, химические и электрические. В настоящем обзоре рассмотрены некоторые наиболее типичные модели различных типов, используемые на лабораторных крысах. Обобщены результаты применения этих моделей в изучении стимуляции блуждающего нерва как современного метода лечения фармакорезистентной эпилепсии.

Complexity of epilepsy and a seizure as clinical and pathophysiological entities is reflected in a large number of experimental models of epilepsy. They could be stratified into acute and chronic, chemical and electric. The present review describes some most typical non-genetic models of different kinds used on laboratory rats. Also, the results of application of these models for research of vagus nerve stimulation as a novel treatment of drug resistant epilepsy are summarized.

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The authors declare that there are no conflicts of interest present.