transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2018-5-4-12-22transmed-426Research ArticleСЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯCARDIOVASCULAR MEDICINEПолиморфизм генов IL18RAP и IL18R1 ассоциирован с рисками развития инфаркта миокарда у пациентов со стабильной формой ишемической болезни сердцаThe polymorphism of IL18RAP and IL18R1 genes associated with risks of the development of myocardial infarction in patients with stable coronary artery diseaseПонасенкоА. В.PonasenkoA. V.

Понасенко Анастасия Валериевна - кандидат медицинских наук, заведующая лабораторией геномной медицины отдела экспериментальной и клинической кардиологии.

Сосновый бульвар, д. 6, Кемерово, 650002

Ponasenko Anastasia Valerievna - PhD, head of laboratory of genomic medicine, Department of Experimental and Clinical Cardiology.

Sosnoviy blvd., 6 Kemerovo, 650002

ponaav@kemcardio.ruЦепокинаА. В.TsepokinaA. V.

Цепокина Анна Викторовна - младший научный сотрудник лаборатории геномной медицины, отдела экспериментальной и клинической кардиологии.

Сосновый бульвар, д. 6, Кемерово, 650002

Tsepokina Anna Viktorovna - junior researcher of laboratory of genomic medicine, Department of  Experimental and Clinical Cardiology

ХуторнаяМ. В.KhutornayaM. V.

Хуторная Мария Владимировна - младший научный сотрудник лаборатории геномной медицины отдела экспериментальной и клинической кардиологии.

Сосновый бульвар, д. 6, Кемерово, 650002

Khutornaya Mariya Vladimirovna -  junior researcher of laboratory of genomic medicine, Department of Experimental and Clinical Cardiology

ДолгихВ. А.DolgikhV. A.

Долгих Владислав Андреевич – магистрант

Dolgikh Vladislav Andreevich - graduate student

МалышевИ. Ю.MalshevI. Yu.

Малышев Игорь Юрьевич - доктор медицинских наук, профессор, заведующий кафедрой патологической физиологии

Malyshev Igor Yurievich - MD, prof., head of the Department of Pathological Physiology

БарбарашО. Л.BarbarashO. L.

Барбараш Ольга Леонидовна - доктор медицинских наук, член-корреспондент РАН, директор.

Сосновый бульвар, д. 6, Кемерово, 650002

Barbarash Olga Leonidovna - PhD, MD, prof., Corresponding Member of Russian Academy of Sciences, director

Федеральное государственное бюджетное научное учреждение Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний; Федеральное государственное бюджетное образовательное учреждение высшего образования Кемеровский государственный университетРоссияMunicipal Budgetary Healthcare Institution Kemerovo Cardiology Dispensary; Kemerovo State UniversityRussian FederationФедеральное государственное бюджетное научное учреждение Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийРоссияMunicipal Budgetary Healthcare Institution Kemerovo Cardiology DispensaryRussian FederationФедеральное государственное автономное образовательное учреждение высшего образования Новосибирский национальный исследовательский государственный университетРоссияNovosibirsk State UniversityRussian FederationМосковский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияA.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation201830092018541222Copyright © Понасенко А.В., Цепокина А.В., Хуторная М.В., Долгих В.А., Малышев И.Ю., Барбараш О.Л., 20182018Понасенко А.В., Цепокина А.В., Хуторная М.В., Долгих В.А., Малышев И.Ю., Барбараш О.Л.Ponasenko A.V., Tsepokina A.V., Khutornaya M.V., Dolgikh V.A., Malshev I.Y., Barbarash O.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/426Цель

Цель: Оценить вероятность патогенетического влияния полиморфизма генов системы ИЛ-18 (IL18, IL18R1 и IL18RAP) на риск развития инфаркта миокарда у пациентов со стабильной ишемической болезнью сердца.

Материалы и методы

Материалы и методы: Исследование выполнено с включением 260 больных стабильной ишемической болезнью сердца (ИБС), жителей промышленного региона Западной Сибири. Проведено молекулярно-генетическое тестирование по девяти полиморфным сайтам генов IL18, IL18R1, IL18RAP.

Результаты

Результаты: Определены ассоциации полиморфных сайтов rs13015714 IL18R1 и rs917997 IL18RAP с рисками развития инфаркта миокарда (ОШ =1,95 (95%ДИ =1,06-3,58), р =0,029 и ОШ =2,01 (95%ДИ =1,11-3,64), р=0,018).

Заключение

Заключение: Для подтверждения роли полиморфизма IL18, IL18R1, IL18RAP в патогенезе атеросклероза необходимо проспективное наблюдение за этой группой пациентов с целью выявления случаев манифестации клинических признаков у лиц, имеющих неблагоприятный прогноз.

Objective

Objective: to assess the probability of pathogenic effects OF Il-18 (IL18, IL18R1 and IL18RAP) gene polymorphism on the risk of myocardial infarction in patients with stable coronary heart disease.

Materials and methods

Materials and methods: the present study was performed with the inclusion of 260 patients with stable coronary heart disease (CHD), residents of the industrial region of Western Siberia. Molecular genetic testing was performed on nine polymorphic sites of il18, IL18R1, IL18RAP genes.

Results

Results: associations of polymorphic sites rs13015714 IL18R1 and rs917997 IL18RAP with risks of myocardial infarction were Determined (OR =1.95 (95% CI =1.06-3.58), p =0.029 and OR =2.01 (95% CI =1.11-3.64), p=0.018).

Conclusion

Conclusion: to confirm the role of polymorphism IL18, IL18R1, IL18RAP in the pathogenesis of atherosclerosis, prospective monitoring of this group of patients is necessary to identify cases of manifestation of clinical signs in persons with adverse prognosis.

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The authors declare that there are no conflicts of interest present.