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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transmed</journal-id><journal-title-group><journal-title xml:lang="ru">Трансляционная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Translational Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-4495</issn><issn pub-type="epub">2410-5155</issn><publisher><publisher-name>Almazov National Medical Research Centre, Saint Petersburg, Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2311-4495-2018-5-2-5-14</article-id><article-id custom-type="elpub" pub-id-type="custom">transmed-381</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOVASCULAR MEDICINE</subject></subj-group></article-categories><title-group><article-title>АНАЛИЗ ПРИЧИН ПОЗДНЕЙ ДИАГНОСТИКИ МИОКАРДИТА</article-title><trans-title-group xml:lang="en"><trans-title>ANALYSIS OF THE REASONS OF LATER DIAGNOSTICS  OF MYOCARDITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Софья Вадимовна – ординатор.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Sofya V. Ivanova - medical resident.</p><p>Akkuratova str. 2, Saint Petersburg, 197341</p></bio><email xlink:type="simple">sonya.spbgmu16@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Titov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Титов Владислав Андреевич - врач-кардиолог.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Vladislav A. Titov – MD.</p><p>Saint Petersburg</p></bio><email xlink:type="simple">titovvladislove@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митрофанова</surname><given-names>Л. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Mitrofanov</surname><given-names>L. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Митрофанова Любовь Борисовна - доктор медицинских наук, зав НИЛ Патоморфологии.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Lubov` B. Mitrofanova - PhD, prof., Head of the laboratory of pathomorphology.</p><p>Saint Petersburg</p></bio><email xlink:type="simple">lubamitr@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеева</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseeva</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Моисеева Ольга Михайловна - доктор медицинских наук, заведующая научно-исследовательским отделом некоронарогенных заболеваний сердца.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Olga M. Moiseeva - MD, PhD, prof., Head of the Department of Noncoronary Diseases.</p><p>Saint Petersburg</p></bio><email xlink:type="simple">moiseeva@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр  им. В. А. Алмазова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>17</day><month>06</month><year>2018</year></pub-date><volume>5</volume><issue>2</issue><fpage>5</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иванова С.В., Титов В.А., Митрофанова Л.Б., Моисеева О.М., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Иванова С.В., Титов В.А., Митрофанова Л.Б., Моисеева О.М.</copyright-holder><copyright-holder xml:lang="en">Ivanova S.V., Titov V.A., Mitrofanov L.B., Moiseeva O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://transmed.almazovcentre.ru/jour/article/view/381">https://transmed.almazovcentre.ru/jour/article/view/381</self-uri><abstract><p>Верификация диагноза «миокардит», несмотря на активное внедрение современных методов обследования, по-прежнему сложна, что приводит не только к поздней постановке заболевания, но и ухудшению прогноза пациентов.</p><p>Цель настоящего исследования – выявить причины поздней диагностики воспалительных заболеваний миокарда, оценить факторы, влияющие на течение заболевания, и эффективность проводимой терапии у пациентов с морфологически документированным миокардитом.</p><p>В исследовании приняли участие 50 пациентов с морфологически документированным миокардитом. длительность наблюдения составила 3,5±1,6 года. в 59% случаев диагноз «миокардит» верифицирован в сроки, превышающие 6 месяцев от первых клинико-инструментальных проявлений. Отдаленный прогноз пациентов в отношении глобальной сократительной способности левого желудочка зависел от сроков верификации диагноза (c² = 6,9; р &lt;0,05) и клинического варианта дебюта миокардита (c² = 13,7; р &lt;0,01). Отмечено достоверное ухудшение прогноза пациентов, имеющих в дебюте заболевания клинику сердечной недостаточности и нарушения ритма, а также пациентов с поздней диагностикой заболевания вследствие ошибочной его трактовки. Сделан вывод о том, что наличие идиопатических нарушений ритма должно рассматриваться как повод для исключения миокардита у пациентов с уже диагностированными болезнями сердца. Доказано улучшение прогноза на фоне комбинированной терапии сердечной недостаточности (иАПФ, бета-адреноблокаторы и диуретики) (c² = 9,28; p &lt;0,01) и приема статинов (c² = 6,04; р &lt;0,05).</p></abstract><trans-abstract xml:lang="en"><p>The verification of the diagnosis of “myocarditis”, despite the active introduction of modern survey methods, is still complicated, which leads not only to late diagnosis, but also to worsening the prognosis of patients. The purpose of this study was to identify the causes of late diagnosis of inflammatory diseases of the myocardium, evaluate the factors influencing the course of the disease, and the effectiveness of the therapy in patients with morphologically documented myocarditis. The study involved 50 patients with morphologically documented myocarditis. The duration of follow-up was 3.5±1.6 years. In 59% of cases, myocarditis was diagnosed within a period exceeding 6 months of the first clinical and instrumental manifestations. Long-term prognosis of patients with regard to global contractility of the left ventricle depended on the timing of verification of the diagnosis (c² = 6.9, p &lt;0.05) and the clinical variant of the debut of the myocarditis (c² = 13.7, p &lt;0.01). There was a significant deterioration in the prognosis in  patients who have a heart failure clinic and rhythm disorders in the onset of the disease, as well as in patients with late diagnosis of the disease due to erroneous treatment. It was concluded that the presence of idiopathic rhythm disturbances should be considered as an excuse for excluding myocarditis in patients with already diagnosed heart diseases. The study proved an improvement in the prognosis on the background of combined therapy for heart failure (ACE inhibitors, beta-blockers and diuretics) (c² = 9.28, p &lt;0.01), and statin therapy (c² = 6.04, p &lt;0.05).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>миокардит</kwd><kwd>диагностика</kwd><kwd>прогноз</kwd><kwd>терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>myocarditis</kwd><kwd>diagnosis</kwd><kwd>prognosis</kwd><kwd>therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Моисеева О.М. Миокардит: основные принципы диагностики и лечения. Кардиология: новости, мнения, обучение. 2016; 1(8): 50−64.</mixed-citation><mixed-citation xml:lang="en">Moiseeva OM. Myocarditis: the basic principles of diagnosis and treatment. Kardiologiya: novosti, mneniya, obucheniye= Cardiology: news, opinions, training. 2016; 1(8): 50−64. 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In Russian</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
