<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transmed</journal-id><journal-title-group><journal-title xml:lang="ru">Трансляционная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Translational Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-4495</issn><issn pub-type="epub">2410-5155</issn><publisher><publisher-name>Almazov National Medical Research Centre, Saint Petersburg, Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2311-4495-2018-5-1-53-59</article-id><article-id custom-type="elpub" pub-id-type="custom">transmed-371</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group></article-categories><title-group><article-title>ТРАНСТОРАКАЛЬНОЕ УЛЬТРАЗВУКОВОЕ ДОППЛЕРОВСКОЕ ИССЛЕДОВАНИЕ ПЕРЕДНЕЙ МЕЖЖЕЛУДОЧКОВОЙ АРТЕРИИ КАК АЛЬТЕРНАТИВА ОПРЕДЕЛЕНИЯ МГНОВЕННОГО БЕЗВОЛНОВОГО СООТНОШЕНИЯ ПРИ ЧРЕСКОЖНОМ КОРОНАРНОМ ВМЕШАТЕЛЬСТВЕ У ПАЦИЕНТКИ ПОЖИЛОГО ВОЗРАСТА</article-title><trans-title-group xml:lang="en"><trans-title>TRANSTHORACIC COLOR (DOPLER) ULTRASOUND OF LEFT ANTERIOR DESCENDING ARTERY AS ALTERNATIVE TO IMMEDIATE INSTANT WAVE­FREE RATIO FOR PERCUTANEOUS CORONARY INTERVENTION IN ELDERLY PATIENTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Агарков</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Agarkov</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Агарков Максим Васильевич - младший научный сотрудник лаборатории возрастной патологии сердечно-сосудистой системы СП ИБГ СЗО РАМН, рентгенэндоваскулярный хирург отделения рентгенохирургических методов диагностики и лечения СПБ ГБ № 40</p></bio><bio xml:lang="en"><p>Maxim V. Agarkov - junior researcher, department of clinical gerontology and geriatrics St.PIBG; interventional radiologist of radiology-endovascular department of CH № 40</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьёвский</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorobevskii</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воробьёвский Дмитрий Александрович - младший научный сотрудник лаборатории возрастной патологии сердечно-сосудистой системы СП ИБГ СЗО РАМН, рентгенэндоваскулярный хирург отделения рентгенохирургических методов диагностики и лечения СПБ ГБ № 40</p></bio><bio xml:lang="en"><p>Dmitrii A. Vorobevskii -  junior researcher, department of clinical gerontology and geriatrics St.PIBG; interventional radiologist of radiology-endovascular department CH № 40</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осадчий</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Osadchii</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Осадчий Андрей Михайлович - кандидат медицинских наук, рентгенэндоваскулярный хирург отделения рентгенохирургических методов диагностики и лечения СПБ ГБ № 40</p></bio><bio xml:lang="en"><p>Andrei M. Osadchii - PhD, interventional radiologist of radiology-endovascular department CH № 40.</p><p>Borisova str. 9, Sestroretsk, 197706</p></bio><email xlink:type="simple">an_osadchy@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлова</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlova</surname><given-names>N. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павлова Наталья Евгеньевна - врач отделения функциональной диагностики СПБ ГБ № 40</p></bio><bio xml:lang="en"><p>Nataliya E. Pavlova - specialist of functional diagnostics department CH № 40</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Власенко</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vlasenko</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Власенко Сергей Васильевич - кандидат медицинских наук, преподаватель кафедры последипломного образования Медицинского факультета СПГУ, заведующий отделением рентгенохирургических методов диагностики и лечения СПБ ГБ № 40</p></bio><bio xml:lang="en"><p>Sergei V. Vlasenko - PhD, associate professor of postgraduate medical department St.PSU, chief of radiology-endovascular department CH № 40</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>К. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>K. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козлов Кирилл Ленарович - доктор медицинских наук, профессор, заведующий отделом клинической геронтологии и гериатрии СП ИБГ СЗО РАМН</p></bio><bio xml:lang="en"><p>Kirill L. Kozlov - MD, Professor, chief of Department of clinical gerontology and geriatrics St.PIBG</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамаева</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamaeva</surname><given-names>O. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мамаева Ольга Петровна - кандидат медицинских наук, заведующая отделением функциональной диагностики СПБ ГБ № 40</p></bio><bio xml:lang="en"><p>Olga P. Mamaeva - PhD, chief of functional diagnostics department CH № 40</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хильчук</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khilchuk</surname><given-names>А. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хильчук Антон Андреевич - рентгенэндоваскулярный хирург отделения рентгенохирургических методов диагностики и лечения СПБ ГБУЗ «Городская больница № 40» МЗ РФ</p></bio><bio xml:lang="en"><p>Anton A. Khilchuk - interventional radiologist of radiology-endovascular department CH № 40</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щербак</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Sherbak</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щербак Сергей Григорьевич - доктор медицинских наук, профессор, заведующий кафедрой последипломного образования Медицинского факультета СПГУ, главный врач СПб ГБ № 40</p></bio><bio xml:lang="en"><p>Sergei G. Sherbak - MD, PhD, Dr Med Sci, Professor, head of Postgraduate Medical education at St.PSU, chief physician CH № 40</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сарана</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sarana</surname><given-names>А. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сарана Андрей Михайлович - кандидат медицинских наук, доцент кафедры последипломного образования Медицинского факультета СПГУ, заместитель главного врача по реабилитации СПБ ГБ № 40</p></bio><bio xml:lang="en"><p>Andrei M Sarana - PhD, associate professor of postgraduate medical Department St.PSU, deputy chief physician in rehabilitation CH № 40</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедева</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedeva</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебедева Светлана Владимировна - заместитель главного врача по терапии, руководитель регионального сердечно-сосудистого центра СПБ ГБ № 40 </p></bio><bio xml:lang="en"><p>Svetlana V. Lebedeva - chief of regional cardiovascular center, deputy chief physician in therapy CH № 40</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белокопытов</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Belokopytov</surname><given-names>I. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белокопытов Игорь Юрьевич - кандидат медицинских наук, доцент кафедры последипломного образования Медицинского факультета СПГУ</p></bio><bio xml:lang="en"><p>Igor Y. Belokopytov - Candidate of Medical Sciences, Associate Professor of Postgraduate Medical Department  St. PSU </p></bio><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шендеров</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shenderov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шендеров Сергей Валерьевич - младший научный сотрудник лаборатории возрастной патологии сердечно-сосудистой системы СП ИБГ СЗО РАМН, заведующий отделением рентгенохирургических методов диагностики и лечения СПб ГБ № 26</p></bio><bio xml:lang="en"><p>Sergei V. Shenderov - juor researcher, department of clinical gerontology and geriatrics St.PIBG, chief of radiology-endovascular department CH № 26</p></bio><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курникова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurnikova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Курникова Елена Анатольевна - кандидат медицинских наук, кардиолог отделения рентгенохирургических методов диагностики и лечения СПб ГБ № 26</p></bio><bio xml:lang="en"><p>Elena A. Kurnikova - cardiologist of radiology-endovascular department CH № 26</p></bio><xref ref-type="aff" rid="aff-8"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>СПб ГБУЗ Городская больница №40 Курортного района; АНО НИЦ Санкт-Петербургский институт биорегуляции и геронтологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital № 40; Saint Petersburg Institute of Bioregulation and Gerontology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>СПб ГБУЗ Городская больница №40 Курортного района</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital № 40</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>СПб ГБУЗ Городская больница №40 Курортного района; Санкт-Петербургский Государственный Университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital № 40; Saint Petersburg University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>АНО НИЦ Санкт-Петербургский институт биорегуляции и геронтологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg Institute of Bioregulation and Gerontology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>СПб ГБУЗ Городская больница №40 Курортного района</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital № 40; Saint Petersburg University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Санкт-Петербургский Государственный Университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>АНО НИЦ Санкт-Петербургский институт биорегуляции и геронтологии; СПб ГБУЗ Городская больница №26</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg Institute of Bioregulation and Gerontology; City Hospital № 26</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>СПб ГБУЗ Городская больница №26</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital № 26</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>26</day><month>04</month><year>2018</year></pub-date><volume>5</volume><issue>1</issue><fpage>53</fpage><lpage>59</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Агарков М.В., Воробьёвский Д.А., Осадчий А.М., Павлова Н.Е., Власенко С.В., Козлов К.Л., Мамаева О.П., Хильчук А.А., Щербак С.Г., Сарана А.М., Лебедева С.В., Белокопытов И.Ю., Шендеров С.В., Курникова Е.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Агарков М.В., Воробьёвский Д.А., Осадчий А.М., Павлова Н.Е., Власенко С.В., Козлов К.Л., Мамаева О.П., Хильчук А.А., Щербак С.Г., Сарана А.М., Лебедева С.В., Белокопытов И.Ю., Шендеров С.В., Курникова Е.А.</copyright-holder><copyright-holder xml:lang="en">Agarkov M.V., Vorobevskii D.A., Osadchii A.M., Pavlova N.E., Vlasenko S.V., Kozlov K.L., Mamaeva O.P., Khilchuk А.A., Sherbak S.G., Sarana А.M., Lebedeva S.V., Belokopytov I.Y., Shenderov S.V., Kurnikova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://transmed.almazovcentre.ru/jour/article/view/371">https://transmed.almazovcentre.ru/jour/article/view/371</self-uri><abstract><p>Современная доктрина лечения ишемической болезни сердца (ИБС) направлена на выбор метода, который будет максимально эффективен и безопасен для пациента. В настоящее время существуют три подхода к лечению стабильной ИБС: консервативная терапия, чрескожное коронарное вмешательство (ЧКВ) и аорто-коронарное шунтирование (АКШ). У каждого варианта лечения есть свои показания и противопоказания, основанные на международных рекомендациях. Отдельной противоречивой группой считаются пациенты пожилого и старческого возраста. Пониженная физическая активность, обширный коморбидный фон, высокий риск послеоперационных осложнений после АКШ и при назначении двойной антиагрегантной терапии после ЧКВ, требуют от врача строгий индивидуальный подход к каждому пациенту и четкую обоснованность метода лечения. Оперативное вмешательство возможно только после того, как ишемия миокарда будет доказана либо неинвазивными визуализирующими тестами, либо методом оценки фракционированного резерва кровотока (FFR, ФРК) или его альтернативой – мгновенного безволнового соотношения (iFR, МБС) – во время коронарографии. Определение гемодинамической значимости стеноза артерии в дальнейшем помогает избежать неоправданных реваскуляризаций и, как следствие, предотвратить осложнения, связанные с операцией.</p></abstract><trans-abstract xml:lang="en"><p>The modern doctrine of treating ischemic heart disease (IHD) is aimed to choose a method, which maximizes the effectiveness and safety for patients. Currently there are three approaches for treatment of stable IHD: optimal medical therapy, percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Each approach has own indications and contraindications, based on international recommendations. Separate controversial group of patients are the elderly and senile patients. Limited physical activity, comorbidities, high complications risk in post-PCI double antiplatelet therapy and after CABG, requires strongly individualized approach and proved treatment method. Surgery is possible only after myocardial ischemia is proved by noninvasive imaging methods, assessment of fractional flow reserve (FFR) or its alternative – instant wave-free ratio (iFR) during the coronary angiography. Determination of hemodynamically significant stenosis helps interventional cardiologists to avoid unreasonable revascularization and PCI-related complications.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>реваскуляризация миокарда</kwd><kwd>чрескожное коронарное вмешательство</kwd><kwd>фракционированный резерв кровотока</kwd><kwd>мгновенное безволновое соотношение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>myocardial revascularization</kwd><kwd>percutaneous coronary intervention</kwd><kwd>fractional flow reserve</kwd><kwd>instant wave-free ratio</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кочанов И. Н. Эффективность лечения ишемической болезни сердца методами коронаропластики и стентирования у больных пожилого и старческого возраста: Автореф. дис. канд. мед. наук. СПб; 2007.</mixed-citation><mixed-citation xml:lang="en">Kochanov IN. Efficiency of treatment with coronary angioplasty and stenting in elderly and senile patients with coronary heart disease: The abstract of Cand. Med. Sci. Diss. St. Petersburg; 2007. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Patel MR, Dehmer GJ, Hirshfeld JW, et al.. ACCF/ SCAI/STS/AATS/AHA/ASNC 2009 Appropriateness Criteria for Coronary Revascularization. Circulation. 2009; 119 (9): 1330-1352.</mixed-citation><mixed-citation xml:lang="en">Patel MR, Dehmer GJ, Hirshfeld JW, et al.. ACCF/ SCAI/STS/AATS/AHA/ASNC 2009 Appropriateness Criteria for Coronary Revascularization. Circulation. 2009; 119 (9): 1330-1352.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">2014 ESC/EACTS Guidelines on myocardial revascularization: the Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur. Heart J. 2014; 35 (37): 2541-2619.</mixed-citation><mixed-citation xml:lang="en">2014 ESC/EACTS Guidelines on myocardial revascularization: the Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur. Heart J. 2014; 35 (37): 2541-2619.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lin GA, Dudley RA, Lucas FL, et al. Frequency of stress testing to document ischemia prior to elective percutaneous coronary intervention. JAMA. 2008; 300 (15): 1765-1773.</mixed-citation><mixed-citation xml:lang="en">Lin GA, Dudley RA, Lucas FL, et al. Frequency of stress testing to document ischemia prior to elective percutaneous coronary intervention. JAMA. 2008; 300 (15): 1765-1773.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lindstaedt M, Spiecker M, Perings C, et al. How good are experienced interventional cardiologists at predicting the functional significance of intermediate or equivocal left main coronary artery stenoses? Int. J. Cardiol. 2007; 120 (21): 254-261.</mixed-citation><mixed-citation xml:lang="en">Lindstaedt M, Spiecker M, Perings C, et al. How good are experienced interventional cardiologists at predicting the functional significance of intermediate or equivocal left main coronary artery stenoses? Int. J. Cardiol. 2007; 120 (21): 254-261.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Brueren BR, ten Berg JM, Suttorp MJ, et al. How good are experienced cardiologists at predicting the hemodynamic severity of coronary stenoses when taking fractional flow reserve as the gold standard. Int. J. Cardiovasc. Imaging. 2002; 18 (2): 73-76.</mixed-citation><mixed-citation xml:lang="en">Brueren BR, ten Berg JM, Suttorp MJ, et al. How good are experienced cardiologists at predicting the hemodynamic severity of coronary stenoses when taking fractional flow reserve as the gold standard. Int. J. Cardiovasc. Imaging. 2002; 18 (2): 73-76.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N. Engl. J. Med. 2009; 360 (3): 213-224.</mixed-citation><mixed-citation xml:lang="en">Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N. Engl. J. Med. 2009; 360 (3): 213-224.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tonino PA, Fearon WF, De Bruyne B, et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J. Am. Coll. Cardiol. 2010; 55 (25): 2816-2821.</mixed-citation><mixed-citation xml:lang="en">Tonino PA, Fearon WF, De Bruyne B, et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J. Am. Coll. Cardiol. 2010; 55 (25): 2816-2821.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Escaned J, Echavarría-Pinto M, Garcia-Garcia HM, et al. Prospective Assessment of the Diagnostic Accuracy of Instantaneous Wave-Free Ratio to Assess Coronary Stenosis Relevance. JACC Cardiovasc Interv. 2015; 8 (6): 824-833.</mixed-citation><mixed-citation xml:lang="en">Escaned J, Echavarría-Pinto M, Garcia-Garcia HM, et al. Prospective Assessment of the Diagnostic Accuracy of Instantaneous Wave-Free Ratio to Assess Coronary Stenosis Relevance. JACC Cardiovasc Interv. 2015; 8 (6): 824-833.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lindner JR. The Physiologic Evaluation of Stenosis by Transthoracic Doppler: A Bit of Theory, a Lot of Practice. J. Am. Soc. Echocardiogr. 2011; 24 (4): 382–384.</mixed-citation><mixed-citation xml:lang="en">Lindner JR. The Physiologic Evaluation of Stenosis by Transthoracic Doppler: A Bit of Theory, a Lot of Practice. J. Am. Soc. Echocardiogr. 2011; 24 (4): 382–384.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Boshchenko A. Transthoracic coronary flow reserve in the left anterior and posterior descending arteries as an additional option to stress echocardiography with wall motion analysis. Eur. Heart J. Cardiovasc. Imaging. 2013; 14, suppl. 2: ii1-ii2.</mixed-citation><mixed-citation xml:lang="en">Boshchenko A. Transthoracic coronary flow reserve in the left anterior and posterior descending arteries as an additional option to stress echocardiography with wall motion analysis. Eur. Heart J. Cardiovasc. Imaging. 2013; 14, suppl. 2: ii1-ii2.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J. Hypertens. 2003; 21 (6): 1011–1053.</mixed-citation><mixed-citation xml:lang="en">European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J. Hypertens. 2003; 21 (6): 1011–1053.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sen S, Asrress KN, Nijjer S, et al. Diagnostic classification of the instantaneous wave-free ratio is equivalent to fractional flow reserve and is not improved with adenosine administration. Results of CLARIFY (Classification Accuracy of Pressure- Only Ratios Against Indices Using Flow Study). J Am Coll Cardiol. 2013;61:1409–1420.</mixed-citation><mixed-citation xml:lang="en">Sen S, Asrress KN, Nijjer S, et al. Diagnostic classification of the instantaneous wave-free ratio is equivalent to fractional flow reserve and is not improved with adenosine administration. Results of CLARIFY (Classification Accuracy of Pressure- Only Ratios Against Indices Using Flow Study). J Am Coll Cardiol. 2013;61:1409–1420.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Corban MT, Hung OY, Eshtehardi P, et al. Myocardial bridging: contemporary understanding of pathophysiology with implications for diagnostic and therapeutic strategies. J Am Coll Cardiol 2014;63:2346–2355.</mixed-citation><mixed-citation xml:lang="en">Corban MT, Hung OY, Eshtehardi P, et al. Myocardial bridging: contemporary understanding of pathophysiology with implications for diagnostic and therapeutic strategies. J Am Coll Cardiol 2014;63:2346–2355.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Srinivasan M, Prasad A. Metal fatigue in myocardial bridges: stent fracture limits the efficacy of drug-eluting stents. J Invasive Cardiol 2011;23:E150–2.</mixed-citation><mixed-citation xml:lang="en">Srinivasan M, Prasad A. Metal fatigue in myocardial bridges: stent fracture limits the efficacy of drug-eluting stents. J Invasive Cardiol 2011;23:E150–2.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
