transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2017-4-5-28-36transmed-357Research ArticleАНЕСТЕЗИОЛОГИЯ И РЕАНИМАТОЛОГИЯPAIN, CRITICAL CARE, AND ANESTHESIAРОЛЬ ОБЩИХ АНЕСТЕТИКОВ В МОДУЛЯЦИИ СИСТЕМНОГО ВОСПАЛИТЕЛЬНОГО ОТВЕТА В ПЕРИОПЕРАЦИОННОМ ПЕРИОДЕTHE ROLE OF GENERAL ANESTHETICS IN MODULATION OF THE SYSTEMIC INFLAMMATION RESPONSE DURING PERIOPERATIVE PERIODСаввинаИ. А.SavvinaI. A.

д.м.н., доцент, гл. науч. сотрудник «Российского научно-исследовательского нейрохирургического института им. проф. А. Л. Поленова» филиала ФГБУ «Национальный медицинский исследовательский центр им. В. А. Алмазова» Минздрава Росси, проф. кафедры анестезиологии и реаниматологии им. В. Л. Ваневского ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И. И. Мечникова» Минздрава России;

MD, PhD, Almazov National Medical Research Centre, chief research scientist of Russian Polenov Neurosurgical Institute, associate professor, North-West State Mechnikov Medical University, professor of the chair of anaesthesiology and reanimatology named after V.L.Vanevskiy;

irinasavvina@mail.ruКостареваА. А.KostarevaA. A.

к.м.н., директор Института молекулярной биологии и генетики ФГБУ «Национальный медицинский исследовательский центр им. В. А. Алмазова» Минздрава России;

MD, PhD, Director of the Institute of molecular biology and genetics, Almazov National Medical Research Centre;

akostareva@hotmail.comФедоровА. В.FedorovA. V.

к.б.н., зав. НИЛ молекулярно-клеточных механизмов атеросклероза Института молекулярной биологии и генетики ФГБУ «Национальный медицинский исследовательский центр им. В. А. Алмазова» Минздрава России;

PhD, Head of the laboratory of molecular and cellular mechanisms of atherosclerosis, Institute of molecular biology and genetics, Almazov National Medical Research Centre;

an_nt@mail.ruРутковскийР. В.RutkovskiyR. V.

зав.отделением анестезиологии и реанимации с палатами интенсивной терапии № 12 ФГБУ «Национальный медицинский исследовательский центр им. В. А. Алмазова » Минздрава России;

Head of the department of anaesthesiology, reanimatology and intensive care, Almazov National Medical Research Centre;

Roman.rutkovskiy@gmail.comРаспутинаД. А.RasputinaD. A.

врач анестезиолог-реаниматолог отделения анестезиологии и реанимации с палатами интенсивной терапии № 12 ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России;

anaesthesiologist-reanimatologist of the department of anaesthesiology, reanimatology and intensive care, Almazov National Medical Research Centre;

dasharasputina@mail.ruМалхозоваА. М.MalkhozovaA. M.

врач анестезиолог-реаниматолог отделения анестезиологии и реанимации с палатами интенсивной терапии № 12 ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России;

anaesthesiologist-reanimatologist of the department of anaesthesiology, reanimatology and intensive care, Almazov National Medical Research Centre

amalkhozova@bk.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр им. В. А. Алмазова»РоссияAlmazov National Medical Research CentreRussian Federation201725122017452836Copyright © Саввина И.А., Костарева А.А., Федоров А.В., Рутковский Р.В., Распутина Д.А., Малхозова А.М., 20172017Саввина И.А., Костарева А.А., Федоров А.В., Рутковский Р.В., Распутина Д.А., Малхозова А.М.Savvina I.A., Kostareva A.A., Fedorov A.V., Rutkovskiy R.V., Rasputina D.A., Malkhozova A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/357

Общие анестетики оказывают воздействие на иммунную систему. Такая иммуномодуляция может иметь как отрицательный, так и положительный эффект на исход хирургического вмешательства и отдаленные результаты лечения. Публикация посвящена обсуждению и систематизации данных о нарушении регуляции иммунной системы в периоперационном периоде, эффектах некоторых наиболее распространенных препаратов для анестезии на клетки иммунной системыи цитокины, а также возможные клинические проявления иммуномодуляции при использовании общих анестетиков.

General anesthetics affect the immune system. Such immunomodulation can have both a negative and a positive effect on the outcome of surgical intervention and distant treatment results. Current review is devoted to the discussion and systematization of data on deregulation of the immune system in the perioperative period, the effects of some of the most common anesthetics on the immune cells and cytokines, as well as possible clinical manifestations of immunomodulation using general anesthetics.

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The authors declare that there are no conflicts of interest present.