transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2014-0-3-29-38transmed-34Research ArticleМОЛЕКУЛЯРНАЯ БИОЛОГИЯ И ГЕНЕТИКАМежгенотипные рекомбинанты вируса гепатита с - природные модели для изучения молекулярно-генетических детерминант резистентности вируса к действию противовирусных препаратовHEPATITIS C VIRUS INTERGENOTYPIC RECOMBINANTS: THE NATURAL MODEL FOR STUDYING MOLECULAR GENETIC DETERMINANTS OF VIRAL RESISTANCE TO ANTIVIRAL DRUGSКалининаОльга ВикторовнаKalininaO. V.olgakalinina@mail.ruДудинаКристина РубеновнаDudinaK. R.noemail@neicon.ruКозинаАнастасия НиколаевнаKozinaA. N.noemail@neicon.ruДмитриевАлександр ВалентиновичDmitrievA. V.noemail@neicon.ruИсагулянцМария ГеоргиевнаIsaguliantsM. G.noemail@neicon.ruЗнойкоОльга ОлеговнаZnoikoO. O.noemail@neicon.ruФБУН «Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. Пастера» РоспотребнадзораРоссияSaint-Petersburg Pasteur Epidemiology and Microbiology Research InstituteRussian FederationГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияMoscow State University of Medicine and DentistryRussian FederationФГБУ «Научно-исследовательский институт экспериментальной медицины» СЗО РАМНРоссияResearch Institute of Experimental Medicine of the NorthWest Branch of the Russian Academy of Medical SciencesRussian FederationФГБУ «Научно-исследовательский институт вирусологии им. Д.И. Ивановского» Минздрава РоссииРоссияIvanovskiy Research Institute of VirologyRussian Federation201423122016032938Copyright © Калинина О.В., Дудина К.Р., Козина А.Н., Дмитриев А.В., Исагулянц М.Г., Знойко О.О., 20162016Калинина О.В., Дудина К.Р., Козина А.Н., Дмитриев А.В., Исагулянц М.Г., Знойко О.О.Kalinina O.V., Dudina K.R., Kozina A.N., Dmitriev A.V., Isaguliants M.G., Znoiko O.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/34

В работе представлены данные об организации генома межгенотипных рекомбинантов вируса гепатита С, описаны отличительные особенности генетических детерминант, потенциально вовлеченных в формирование резистентности к действию интерферона, обобщены результаты лечения пациентов, инфицированных рекомбинантными формами вируса гепатита С.

Review presents the current data on the genome organization of the hepatitis C virus intergenotypic recombinants, the peculiarities of genetic determinants potentially involved in the interferon resistant phenotype, summarizes the antiviral therapy outcomes for patients infected by hepatitis C virus recombinants.

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The authors declare that there are no conflicts of interest present.