transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2016-3-6-15-20transmed-268Research ArticleЭНДОКРИНОЛОГИЯENDOCRINOLOGYИЗМЕНЕНИЕ УРОВНЕЙ ЦИРКУЛИРУЮЩИХ МИКРОРНК ПРИ ПАТОГЕНЕЗЕ ГЕНЕТИЧЕСКИ ОБУСЛОВЛЕННОГО САХАРНОГО ДИАБЕТА ВЗРОСЛЫХ У МОЛОДЫХCHANGES IN CIRCULATING MICRORNA LEVELS DURING PATHOGENESIS OF GENETICALLY DETERMINED MATURITY ONSET DIABETES OF THE YOUNGПетроваТ. А.PetrovaT. A.

Петрова Татьяна Александровна - кандидат биологических наук, научный сотрудник НИЛ молекулярной кардиологии Института молекулярной биологии и генетики.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341, e-mail: tatianakhod@gmail.com

Tatiana A. Petrova  - PhD, Researcher, laboratory of molecular cardiology, Institute of molecular biology and genetics.

Akkuratova str. 2, Saint Petersburg, 197341, e-mail: tatianakhod@gmail.com

 

tatianakhod@gmail.comКондратовК. А.KondratovK. A.

Кондратов Кирилл Александрович - кандидат биологических наук, старший научный сотрудник НИЛ молекулярно-клеточных    механизмов    атеросклероза Института  молекулярной  биологии  и  генетики. 

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Kirill A. Kondratov  - PhD, Senior researcher, laboratory of molecular and cellular mechanisms of atherosclerosis, Institute of molecular biology and genetics.

Akkuratova str. 2, Saint Petersburg, 197341

ФедоровА. В.FedorovA. V.

Федоров Антон Владимирович - кандидат биологических наук, зав. НИЛ молекулярно-клеточных    механизмов    атеросклероза Института  молекулярной  биологии  и  генетики.

Ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341

Anton V. Fedorov - PhD, Head of the laboratory of molecular and cellular mechanisms of atherosclerosis, Institute of molecular biology and genetics.

Akkuratova str. 2, Saint Petersburg, 197341

НикитинаИ. Л.NikitinaI. L.

Никитина Ирина Леоровна - доктор медицинских наук, зав. кафедрой детских болезней, заведующая НИЛ детской эндокринологии.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Irina L. Nikitina  - MD, Head of the laboratory of pediatric endocrinology, Institute of endocrinology.

Akkuratova str. 2, Saint Petersburg, 197341

АртемьеваИ. Ю.ArtemevaI. Y.

 

Артемьева Ирина Юрьевна - научный сотрудник НИЛ детской эндокринологии.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Irina Y. Artemeva - Researcher laboratory  of  pediatric endocrinology, Institute of endocrinology.

Akkuratova str. 2, Saint Petersburg, 197341

КостареваА. А.KostarevaA. A.

 

Костарева  Анна  Александровна - кандидат медицинских наук,  директор Института  молекулярной  биологии  и  генетики.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

 

Anna A. Kostareva - MD, PhD, Head of the Institute of molecular biology and genetics.

Akkuratova str. 2, Saint Petersburg, 197341

Северо-Западный федеральный медицинский исследовательский центр имени В. А. АлмазоваРоссияFederal Almazov North-West Medical Research CentreRussian Federation201605042017361520Copyright © Петрова Т.А., Кондратов К.А., Федоров А.В., Никитина И.Л., Артемьева И.Ю., Костарева А.А., 20172017Петрова Т.А., Кондратов К.А., Федоров А.В., Никитина И.Л., Артемьева И.Ю., Костарева А.А.Petrova T.A., Kondratov K.A., Fedorov A.V., Nikitina I.L., Artemeva I.Y., Kostareva A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/268

Сахарный диабет взрослого типа у молодых или MODY-диабет представляет собой моногенную форму диабета, возникающую при генетических нарушениях функционирования β-клеток поджелудочной железы. Сложность диагностирования данного типа диабета состоит в мягком проявлении заболевания и перекрывании клинических симптомов MODY-диабета с симптомами диабетов других типов. Одним из основных критериев постановки диагноза MODY-диабет является обнаружение мутации в генах, связанных с механизмами регуляции синтеза и секреции инсулина. Диагностика MODY-диабета позволяет применять более специфичные схемы лечения, а также выявлять новые случаи данного заболевания, проверяя родственников пациентов. Перспективную группу новых биомаркеров для ранней диагностики данного заболевания представляют собой циркулирующие микроРНК. Данная статья посвящена обзору имеющейся на сегодняшний день информации о микроРНК, уровни которых в биологических жидкостях позволяют выявлять пациентов с различными типами MODY-диабета.

Maturity onset diabetes of the young or MODY is one of the monogenic forms of inherited diabetes, caused by genetic abnormalities in beta cells. Soft manifestation and overlapping clinical symptoms of MODY with common types of diabetes often lead to difficulties in diagnosis. One of the main criteria of correct MODY diagnosis is identification of causative mutations in MODY-related genes. Correct MODY diagnosis enable to apply more specific treatment strategies and identify unobvious cases of the disease by testing relatives of the patients. Circulating microRNAs are promising candidates for early diagnostic biomarkers of the disease. The review focuses on current literature data about MODY-associated microRNA types and their levels in diverse body fluids, which help to identify asymptomatic patients with different MODY types. 

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The authors declare that there are no conflicts of interest present.