transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2014-0-2-58-66transmed-25Research ArticleКАРДИОЛОГИЯCARDIOLOGYБиологическое и клиническое значение исследования «ранних» эндотелиальных клеток-предшественниковBIOLOGICAL AND CLINICAL RELEVANCE OF EARLY ENDOTHELIAL PROGENITOR CELLS RESEARCHКарелкинаЕлена ВикторовнаKarelkinaElena V.ekarelkina@mail.ruМорошкинВиктор СергеевичMoroshkinV. S.noemail@neicon.ruСелютинАлександр ВасильевичSelutinA. V.noemail@neicon.ruБыстроваОльга АлександровнаBistrovaO. A.noemail@neicon.ruМоисееваОльга МихайловнаMoiseevaO. M.noemail@neicon.ruФГБУ «Федеральный медицинский исследовательский центр им. В.А. Алмазова» Минздрава РоссииРоссияFederal Almazov Medical Research CentreRussian FederationНИИ акушерства и гинекологии имени Д.О. Отта РАМНРоссияOtt's Institute of Obstetrics and GynecologyRussian FederationИнститут цитологии РАНРоссияRAS Institute of CytologyRussian Federation201423122016025866Copyright © Карелкина Е.В., Морошкин В.С., Селютин А.В., Быстрова О.А., Моисеева О.М., 20162016Карелкина Е.В., Морошкин В.С., Селютин А.В., Быстрова О.А., Моисеева О.М.Karelkina E.V., Moroshkin V.S., Selutin A.V., Bistrova O.A., Moiseeva O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/25

В статье предпринята попытка оценить клиническое значение и патофизиологический смысл исследования клоногенной способности «ранних» эндотелиальных клеток-предшественников (ЭКП) у больных с факторами риска и хронической сердечной недостаточностью (ХСН) различного генеза. Обследовано 36 больных с ишемической болезнью сердца (ИБС) и систолической дисфункцией левого желудочка (фракция выброса по Симпсону < 40 %), 33 пациента с дилатационной кардиомиопатией (ДКМП), 18 пациентов с гипертонической болезнью II стадии, 2 степени и контрольная группа из 19 практически здоровых лиц. Выполнены клинико-лабораторное обследование и оценка клоногенной способности «ранних» ЭКП по методу J.M. Hill. У пациентов с факторами риска и у больных с ХСН было выявлено снижение колониеобразующей способности «ранних» ЭКП. Низкая пролиферативная активность этих клеток была ассоциирована с увеличением индекса сердечно-сосудистого риска SCORE, гипертрофией и систолической дисфункцией левого желудочка, что указывает на возможность использования данного метода в качестве дополнительного прогностического фактора у больных с сердечно-сосудистыми заболеваниями. Исследование клоногенной способности «ранних» ЭКП сохраняет свои позиции в качестве важного прогностического биомаркера, отражающего ангиогенный потенциал больного.

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The authors declare that there are no conflicts of interest present.