transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2017-4-1-41-48transmed-218Research ArticleТКАНЕВЫЕ, КЛЕТОЧНЫЕ, ГЕНОМНЫЕ И ПРОТЕОМНЫЕ ТЕХНОЛОГИИCELL, TISSUE, AND GENE THERAPYКЛЕТОЧНЫЕ БИОМАРКЕРЫ ПОВРЕЖДЕНИЯ ЭНДОТЕЛИЯ, АССОЦИИРОВАННЫЕ С НЕБЛАГОПРИЯТНЫМ ПРОГНОЗОМ ПРИ ОСТРЫХ КОРОНАРНЫХ СОБЫТИЯХCELLULAR BIOMARKERS OF ENDOTHELIAL DAMAGE ASSOCIATED WITH ADVERSE PROGNOSIS IN ACUTE CORONARY EVENTSАртемоваИ. А.ArtemovaI. A.

Артемова Ирина Александровна – аспирант.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Svetlana N. Kozlova - MD, Professor, Head of Therapeutic Department,  Head of Studies of the Department.

Akkuratova str. 2, Saint Petersburg, 197341

shvedik84@mail.ruКозловаС. Н.KozlovaS. N.

Козлова  Светлана  Николаевна - доктор  медицинских наук, профессор, заведующая учебной частью кафедры   внутренних   болезней, научный руководитель терапевтического отделения.

 Ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Irina A. Artemova - Postgraduate of Internal Medicine Department.

Akkuratova str. 2, Saint Petersburg, 197341

senpolia58@yandex.ruФедеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр им. В. А. Алмазова» Минздрава РоссииРоссияFederal Almazov North-West Medical Research CentreRussian Federation201721022017414148Copyright © Артемова И.А., Козлова С.Н., 20172017Артемова И.А., Козлова С.Н.Artemova I.A., Kozlova S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/218

В данном обзоре литературы клеточные маркеры повреждения эндотелия рассматриваются как новый диагностический и прогностический маркер сердечно-сосудистого риска. Особое значение уделяется эндотелиальной дисфункции как ключевому звену в формировании системной воспалительной реакции и активации коагуляции у пациентов, перенесших острые сердечно-сосудистые события.

This literature review considers the cellular markers of endothelial damage as a new diagnostic and prognostic marker of cardiovascular risk the emphasis is on endothelial dysfunction as a key element in the development of systemic inflammatory response and activation of coagulation in patients after acute cardiovascular events.

микрочастицыпрогениторные клеткиэндотелиальные циркулирующие клеткиэндотелиальная дисфункциямаркер повреждения эндотелияmicroparticlesprogenitor cellscirculating endothelial cellsendothelial dysfunctionmarker of endothelial damageReferencesKern KB, Lotun K, Patel N et al. Outcomes of Comatose Cardiac Arrest Survivors With and Without ST-Segment Elevation Myocardial Infarction: Importance of Coronary Angiography. JACC Cardiovasc Interv. 2015;8(8):1031-40.Kern KB, Lotun K, Patel N et al. Outcomes of Comatose Cardiac Arrest Survivors With and Without ST-Segment Elevation Myocardial Infarction: Importance of Coronary Angiography. JACC Cardiovasc Interv. 2015;8(8):1031-40.Usenko LV, Tsarev AV, Yarovenko VV. Postresuscitative disease: far from the unrealized potential (The current state of the problem). Emergency Medicine. 2008; 4 (17). In Russian [Усенко Л.В., Царев А.В., Яровенко В.В. Постреанимационная болезнь: далеко не реализованный потенциал (Современное состояние проблемы). Медицина неотложных состояний. 2008; 4(17)].Usenko LV, Tsarev AV, Yarovenko VV. Postresuscitative disease: far from the unrealized potential (The current state of the problem). Emergency Medicine. 2008; 4 (17). In Russian [Усенко Л.В., Царев А.В., Яровенко В.В. Постреанимационная болезнь: далеко не реализованный потенциал (Современное состояние проблемы). Медицина неотложных состояний. 2008; 4(17)].Grundmann S, Fink K, Rabadzhieva L et al. Perturbation of the endothelial glycocalixin post cardiac arrest syndrome. Resuscitation. 2012; 83: 715-720.Grundmann S, Fink K, Rabadzhieva L et al. Perturbation of the endothelial glycocalixin post cardiac arrest syndrome. Resuscitation. 2012; 83: 715-720.Lubrano V, Balzan S. Consolidated and emerging inflammatory markers in coronary artery disease. World J Exp Med. 2015;5(1):21-32.Lubrano V, Balzan S. Consolidated and emerging inflammatory markers in coronary artery disease. World J Exp Med. 2015;5(1):21-32.Zamani P, Schwartz GG, Olsson AG et al. Inflammatory biomarkers, death, and recurrent nonfatal coronary events after an acute coronary syndrome in the MIRACL study. Journal of the American Heart Association. 2013;2(1):e003103.Zamani P, Schwartz GG, Olsson AG et al. Inflammatory biomarkers, death, and recurrent nonfatal coronary events after an acute coronary syndrome in the MIRACL study. Journal of the American Heart Association. 2013;2(1):e003103.Berezin AE, Kruzliak P. Circulating endothelial apoptotic microparticles as novel marker of the cardiovascular risk (review). Ukrainian Medical Journal. 2014; 5(103): 83-87. In Russian [Березин А.Е., Крузляк П. Циркулирующие эндотелиальные апоптотические микрочастицы как новый маркер кардиоваскулярного риска (обзор литературы). Украинский медицинский журнал. 2014; 5(103): 83-87].Berezin AE, Kruzliak P. Circulating endothelial apoptotic microparticles as novel marker of the cardiovascular risk (review). Ukrainian Medical Journal. 2014; 5(103): 83-87. In Russian [Березин А.Е., Крузляк П. Циркулирующие эндотелиальные апоптотические микрочастицы как новый маркер кардиоваскулярного риска (обзор литературы). Украинский медицинский журнал. 2014; 5(103): 83-87].Fursov AA, Salmina AB, Sokolovich AG et al. Pathogenesis of a Systemic Inflammatory Reaction: New Aspects. General resuscitation. 2008; 4(2): 84-87. In Russian [Фурсов А.А., Салмина А.Б., Соколович А.Г. и др. Новые аспекты патогенеза системной воспалительной реакции. Общая реаниматология. 2008; 4(2): 84-87].Fursov AA, Salmina AB, Sokolovich AG et al. Pathogenesis of a Systemic Inflammatory Reaction: New Aspects. General resuscitation. 2008; 4(2): 84-87. In Russian [Фурсов А.А., Салмина А.Б., Соколович А.Г. и др. Новые аспекты патогенеза системной воспалительной реакции. Общая реаниматология. 2008; 4(2): 84-87].Korenkov DA, Ovchinnikova OM, Selkov SA et al. Role of microparticles in intercellular communication. Cell and Tissue Biology. 2014; 56(7): 480-488. In Russian [Кореньков АД, Овчинникова ОМ, Сельков СА и др. Роль микрочастиц в межклеточной коммуникации. Цитология. 2014; 56(7): 480-488].Korenkov DA, Ovchinnikova OM, Selkov SA et al. Role of microparticles in intercellular communication. Cell and Tissue Biology. 2014; 56(7): 480-488. In Russian [Кореньков АД, Овчинникова ОМ, Сельков СА и др. Роль микрочастиц в межклеточной коммуникации. Цитология. 2014; 56(7): 480-488].Clifton W, Callaway MD. Endothelial damage after cardiac arrest — “Endotheliitis”. Resuscitation. 2012; 83(6): 667-668.Clifton W, Callaway MD. Endothelial damage after cardiac arrest — “Endotheliitis”. Resuscitation. 2012; 83(6): 667-668.Burger D, Touyz RM. Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells. Journal of the American Society of Hypertension. 2012; 6(2): 85-99.Burger D, Touyz RM. Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells. Journal of the American Society of Hypertension. 2012; 6(2): 85-99.Schiro A, Wilkinson FL, Weston R. Endothelial microparticles as conveyors of information in atherosclerotic disease. Atherosclerosis. 2014; 234: 295-302.Schiro A, Wilkinson FL, Weston R. Endothelial microparticles as conveyors of information in atherosclerotic disease. Atherosclerosis. 2014; 234: 295-302.Enjeti AK, Lincz LF, Seldon M. Microparticles in health and disease. Seminars in thrombosis and hemostasis. 2008; 34 (7): 683-691.Enjeti AK, Lincz LF, Seldon M. Microparticles in health and disease. Seminars in thrombosis and hemostasis. 2008; 34 (7): 683-691.Ermak G, Davies KJ. Calcium and oxidative stress: from cell signaling to cell death. Molecular Immunology. 2002; 38 (10): 713-721.Ermak G, Davies KJ. Calcium and oxidative stress: from cell signaling to cell death. Molecular Immunology. 2002; 38 (10): 713-721.Vion AC, Ramkhelawon B, Loyer X et al. Shear stress regulates endothelial microparticle release. Circulation research. 2013; 112 (10): 1323-1333.Vion AC, Ramkhelawon B, Loyer X et al. Shear stress regulates endothelial microparticle release. Circulation research. 2013; 112 (10): 1323-1333.Shiratsuchi A, Mori T, Nakanishi Y. Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells. Journal of biochemistry. 2002; 132 (3): 381-386.Shiratsuchi A, Mori T, Nakanishi Y. Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells. Journal of biochemistry. 2002; 132 (3): 381-386.Cui Y, Zheng L, Jiang M. et al. Microparticles in patients with coronary heart disease and its correlation with interleukin-6 and C-reactive protein. Molecular biology reports. 2013; 40 (11): 6437-6442.Cui Y, Zheng L, Jiang M. et al. Microparticles in patients with coronary heart disease and its correlation with interleukin-6 and C-reactive protein. Molecular biology reports. 2013; 40 (11): 6437-6442.Adrie C, Monchi M, Laurent I et al. Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway. Journal of the American College of Cardiology. 2005; 46 (1): 21-28.Adrie C, Monchi M, Laurent I et al. Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway. Journal of the American College of Cardiology. 2005; 46 (1): 21-28.Burger D, Montezano AC, Nishigaki N et al. Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(8): 1898–1907.Burger D, Montezano AC, Nishigaki N et al. Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(8): 1898–1907.Dignat-George F, Boulanger CM. The many faces of endothelial microparticles. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31 (1): 27-33.Dignat-George F, Boulanger CM. The many faces of endothelial microparticles. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31 (1): 27-33.Berezin A, Zulli A, Kerrigan S. et al. Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases. Clinical Biochemistry. 2015; 48 (9): 562-568.Berezin A, Zulli A, Kerrigan S. et al. Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases. Clinical Biochemistry. 2015; 48 (9): 562-568.Yuana Y, Sturk A, Nieuwland R. Extracellular vesicles in physiological and pathological conditions. Blood Reviews. 2013; 27: 31-39.Yuana Y, Sturk A, Nieuwland R. Extracellular vesicles in physiological and pathological conditions. Blood Reviews. 2013; 27: 31-39.Lovren F, Verma S. Evolving role of microparticles in the pathophysiology of endothelial dysfunction. Clinical Chemistry. 2013; 59 (8): 1166-1174.Lovren F, Verma S. Evolving role of microparticles in the pathophysiology of endothelial dysfunction. Clinical Chemistry. 2013; 59 (8): 1166-1174.Augustine D, Ayers LV, Lima E et al. Dynamic release and clearance of circulating microparticles during cardiac stress. Circulation Research. 2014; 114 (1): 109-113.Augustine D, Ayers LV, Lima E et al. Dynamic release and clearance of circulating microparticles during cardiac stress. Circulation Research. 2014; 114 (1): 109-113.Arraud N, Linares R, Tan S et al. Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration. Journal of Thrombosis and Haemostasis. 2014; 12 (5): 614-627.Arraud N, Linares R, Tan S et al. Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration. Journal of Thrombosis and Haemostasis. 2014; 12 (5): 614-627.Bernal-Mizrachi L, Jy W, Jimenez JJ et al. High levels of circulating endothelial microparticles in patients with acute coronary syndromes. American Heart Journal. 2003; 145(6): 962-970.Bernal-Mizrachi L, Jy W, Jimenez JJ et al. High levels of circulating endothelial microparticles in patients with acute coronary syndromes. American Heart Journal. 2003; 145(6): 962-970.Empana JP, Boulanger CM, Tafflet M et al. Microparticles and sudden cardiac death due to coronary occlusion. The TIDE (Thrombus and Inflammation in sudden DEath) study. — European heart journal acute cardiovascular care. 2015; 4 (1): 28-36.Empana JP, Boulanger CM, Tafflet M et al. Microparticles and sudden cardiac death due to coronary occlusion. The TIDE (Thrombus and Inflammation in sudden DEath) study. — European heart journal acute cardiovascular care. 2015; 4 (1): 28-36.Boulanger CM, Rautou P-E, Vion A-C et al. Microparticles, vascular function and atherothrombosis. Vascular Pharmacology. 2012; 56(5): 318.Boulanger CM, Rautou P-E, Vion A-C et al. Microparticles, vascular function and atherothrombosis. Vascular Pharmacology. 2012; 56(5): 318.Bernal-Mizrachi L, Jy W, Fierro C et al. Endothelial microparticles correlate with high-risk angiographic lesions in acute coronary syndromes. International journal of cardiology. 2004; 97 (3): 439-46.Bernal-Mizrachi L, Jy W, Fierro C et al. Endothelial microparticles correlate with high-risk angiographic lesions in acute coronary syndromes. International journal of cardiology. 2004; 97 (3): 439-46.Sinning JM, Losch J, Walenta K et al. Circulating CD31+/Annexin V+ microparticles correlate with cardiovascular outcomes. European heart journal. 2011; 32(16): 2034-2041.Sinning JM, Losch J, Walenta K et al. Circulating CD31+/Annexin V+ microparticles correlate with cardiovascular outcomes. European heart journal. 2011; 32(16): 2034-2041.Timmermans F, Plum J, Yöder MC et al. Endothelial progenitor cells: identity defined? Journal of Cellular and Molecular Medicine. 2009; 13 (1): 87-102.Timmermans F, Plum J, Yöder MC et al. Endothelial progenitor cells: identity defined? Journal of Cellular and Molecular Medicine. 2009; 13 (1): 87-102.Hunting CB, Noort WA, Zwaginga JJ. Circulating endothelial (progenitor) cells reflect the state of the endothelium: vascular injury, repair and neovascularization. Vox Sanguinis. 2005; 88 (1): 1-9.Hunting CB, Noort WA, Zwaginga JJ. Circulating endothelial (progenitor) cells reflect the state of the endothelium: vascular injury, repair and neovascularization. Vox Sanguinis. 2005; 88 (1): 1-9.Alexandru N, Andrei E, Dragan E et al. Interaction of platelets with endothelial progenitor cells in the experimental atherosclerosis: Role of transplanted endothelial progenitor cells and platelet microparticles. Biology of the cell. 2015; 107 (6): 189-204.Alexandru N, Andrei E, Dragan E et al. Interaction of platelets with endothelial progenitor cells in the experimental atherosclerosis: Role of transplanted endothelial progenitor cells and platelet microparticles. Biology of the cell. 2015; 107 (6): 189-204.Sarah A, Hubert N, Marie F еt al. Tissue engineering strategies for promoting vascularized bone regeneration. Bone. 2016, 83: 197-209.Sarah A, Hubert N, Marie F еt al. Tissue engineering strategies for promoting vascularized bone regeneration. Bone. 2016, 83: 197-209.Asahara T, Takahashi T, Masuda H еt al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. Embo Journal. 1999; 18 (14): 3964-3972.Asahara T, Takahashi T, Masuda H еt al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. Embo Journal. 1999; 18 (14): 3964-3972.Salmin AB, Morgun AV Kuvacheva NV et al. Endothelial progenitor cells in the development and recovery of cerebral endothelium. Modern medical technology. 2014; 6 (4): 213-222. In Russian [Салмина А.Б., Моргун А.В., Кувачева Н.В. и др. Эндотелиальные прогениторные клетки в развитии и восстановлении церебрального эндотелия. Современные технологии в медицине. 2014; 6(4): 213-222].Salmin AB, Morgun AV Kuvacheva NV et al. Endothelial progenitor cells in the development and recovery of cerebral endothelium. Modern medical technology. 2014; 6 (4): 213-222. In Russian [Салмина А.Б., Моргун А.В., Кувачева Н.В. и др. Эндотелиальные прогениторные клетки в развитии и восстановлении церебрального эндотелия. Современные технологии в медицине. 2014; 6(4): 213-222].Poveshchenko OV, Poveshchenko AF, Konenkov VI. Endothelial progenitor cells and neovaskulogenez. Biology Bulletin Reviews. 2012; 1: 69-76. In Russian [Повещенко О.В., Повещенко А.Ф., Коненков В.И. Эндотелиальные прогениторные клетки и неоваскулогенез. Успехи современной биологии. 2012; 1: 69-76].Poveshchenko OV, Poveshchenko AF, Konenkov VI. Endothelial progenitor cells and neovaskulogenez. Biology Bulletin Reviews. 2012; 1: 69-76. In Russian [Повещенко О.В., Повещенко А.Ф., Коненков В.И. Эндотелиальные прогениторные клетки и неоваскулогенез. Успехи современной биологии. 2012; 1: 69-76].Hill JM, Zalos G, Halcox JP еt al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. New England Journal of Medicine. 2003; 348 (7): 593-600.Hill JM, Zalos G, Halcox JP еt al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. New England Journal of Medicine. 2003; 348 (7): 593-600.Castejon R, Jimenez-Ortiz C, Valero-Gonzalez S et al. Decreased circulating endothelial progenitor cells as an early risk factor of subclinical atherosclerosis in systemic lupus erythematosus. Rheumatology. 2014; 53 (4): 631-638.Castejon R, Jimenez-Ortiz C, Valero-Gonzalez S et al. Decreased circulating endothelial progenitor cells as an early risk factor of subclinical atherosclerosis in systemic lupus erythematosus. Rheumatology. 2014; 53 (4): 631-638.Werner N, Kosiol S, Schiegl T et al. Circulating endothelial progenitor cells and cardiovascular outcomes. New England Journal of Medicine. 2005; 353 (10): 999- 1007.Werner N, Kosiol S, Schiegl T et al. Circulating endothelial progenitor cells and cardiovascular outcomes. New England Journal of Medicine. 2005; 353 (10): 999- 1007.Geft D, Schwartzenberg S, George J. Circulating endothelial progenitor cells in cardiovascular disorders. Expert Review of Cardiovascular Therapy. 2008; 6(8): 1115-1121.Geft D, Schwartzenberg S, George J. Circulating endothelial progenitor cells in cardiovascular disorders. Expert Review of Cardiovascular Therapy. 2008; 6(8): 1115-1121.Liu HB, Gong YF, Yu CJ et al. Endothelial progenitor cells in cardiovascular diseases: from biomarker to therapeutic agent. Regenerative Medicine Research. 2013; 1 (1): 9.Liu HB, Gong YF, Yu CJ et al. Endothelial progenitor cells in cardiovascular diseases: from biomarker to therapeutic agent. Regenerative Medicine Research. 2013; 1 (1): 9.Cuadrado-Godia E, Regueiro A, Nunez J et al. Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy. PLoS ONE. 2015; 10 (9): e0132415.Cuadrado-Godia E, Regueiro A, Nunez J et al. Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy. PLoS ONE. 2015; 10 (9): e0132415.Pirro M, Schillaci G, Bagaglia F et al. Microparticles derived from endothelial progenitor cells in patients at different cardiovascular risk. Atherosclerosis. 2008;197(2):757-767.Pirro M, Schillaci G, Bagaglia F et al. Microparticles derived from endothelial progenitor cells in patients at different cardiovascular risk. Atherosclerosis. 2008;197(2):757-767.Boos CJ, Lip GY, Blann AD. Circulating endothelial cells in cardiovascular disease. Journal of the American College of Cardiology. 2006; 48 (8): 1538-1547.Boos CJ, Lip GY, Blann AD. Circulating endothelial cells in cardiovascular disease. Journal of the American College of Cardiology. 2006; 48 (8): 1538-1547.Erdbruegger U, Haubitz M, Woywodt A. Circulating endothelial cells: a novel marker of endothelial damage. Clinica Chimica Acta. 2006; 373(1): 17-26.Erdbruegger U, Haubitz M, Woywodt A. Circulating endothelial cells: a novel marker of endothelial damage. Clinica Chimica Acta. 2006; 373(1): 17-26.Woywodt A, Scheer J, Hambach L. Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation. Blood. 2004; 103 (9): 3603-3605.Woywodt A, Scheer J, Hambach L. Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation. Blood. 2004; 103 (9): 3603-3605.Blann AD, Woywodt A, Bertolini F. Circulating endothelial cells. Biomarker of vascular disease. Journal of Thrombosis and Haemostasis. 2005; 93 (2): 228-235.Blann AD, Woywodt A, Bertolini F. Circulating endothelial cells. Biomarker of vascular disease. Journal of Thrombosis and Haemostasis. 2005; 93 (2): 228-235.Boos CJ, Balakrishnan B, Jessani S. Effects of percutaneous coronary intervention on peripheral venous blood circulating endothelial cells and plasma indices of endothelial damage/dysfunction. Chest. 2007; 132 (6): 1920-1926.Boos CJ, Balakrishnan B, Jessani S. Effects of percutaneous coronary intervention on peripheral venous blood circulating endothelial cells and plasma indices of endothelial damage/dysfunction. Chest. 2007; 132 (6): 1920-1926.Swerlick RA, Lee KH, Wick TM et al. Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. Journal of Immunology. 1992; 148: 78-83.Swerlick RA, Lee KH, Wick TM et al. Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. Journal of Immunology. 1992; 148: 78-83.Mutin M, Canavy I, Blann A et al. Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. Blood. 1999; 93 (9): 2951-2958.Mutin M, Canavy I, Blann A et al. Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. Blood. 1999; 93 (9): 2951-2958.Damani S, Bacconi A, Libiger O et al. Characterization of circulating endothelial cells in acute myocardial infarction. Science Translational Medicine. 2012; 4 (126): 126ra33.Damani S, Bacconi A, Libiger O et al. Characterization of circulating endothelial cells in acute myocardial infarction. Science Translational Medicine. 2012; 4 (126): 126ra33.Bethel K, Luttgen MS, Damani S et al. Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction. Physics in Medicine and Biology. 2014; 11: 016002.Bethel K, Luttgen MS, Damani S et al. Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction. Physics in Medicine and Biology. 2014; 11: 016002.David E, Schmidt BSc, Marco Manca et al. Circulating endothelial cells in coronary artery disease and acute coronary syndrome. Trends in Cardiovascular Medicine. 2015; 25(7): 578-587.David E, Schmidt BSc, Marco Manca et al. Circulating endothelial cells in coronary artery disease and acute coronary syndrome. Trends in Cardiovascular Medicine. 2015; 25(7): 578-587.Fink K, Schwarz M, Horst C et al. Activated circulating endothelial cells in patients after successful prehospital cardiopulmonary resuscitation. Resuscitation. 2008; 77: S35-S35.Fink K, Schwarz M, Horst C et al. Activated circulating endothelial cells in patients after successful prehospital cardiopulmonary resuscitation. Resuscitation. 2008; 77: S35-S35.Fink K, Schwarz M, Feldbrügge L et al. Severe endothelial injury and subsequent repair in patients after successful cardiopulmonary resuscitation. Critical Care Medicine. 2010; 14 (3): R104.Fink K, Schwarz M, Feldbrügge L et al. Severe endothelial injury and subsequent repair in patients after successful cardiopulmonary resuscitation. Critical Care Medicine. 2010; 14 (3): R104.Brittan M, Hunter A, Skinner EM et al. Vessel wall endothelial cells, but not circulating endothelial progenitor cells, have impaired function in premature coronary artery disease. Atherosclerosis. 2015; 241(1): e73-e73.Brittan M, Hunter A, Skinner EM et al. Vessel wall endothelial cells, but not circulating endothelial progenitor cells, have impaired function in premature coronary artery disease. Atherosclerosis. 2015; 241(1): e73-e73.Marja J, VanBavel E, Sturk A et al. Microparticles in cardiovascular diseases. Cardiovascular Research. 2003; 59 (2): 277-287.Marja J, VanBavel E, Sturk A et al. Microparticles in cardiovascular diseases. Cardiovascular Research. 2003; 59 (2): 277-287.Lin CP, Lin FY, Huang PH et al. Endothelial progenitor cell dysfunction in cardiovascular diseases: role of reactive oxygen species and inflammation. Biomed Res Int. 2013; 2013:845037.Lin CP, Lin FY, Huang PH et al. Endothelial progenitor cell dysfunction in cardiovascular diseases: role of reactive oxygen species and inflammation. Biomed Res Int. 2013; 2013:845037.

The authors declare that there are no conflicts of interest present.