transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2017-4-2-6-16transmed-217Research ArticleСЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯCARDIOVASCULAR MEDICINEСТИМУЛЯЦИЯ БЛУЖДАЮЩЕГО НЕРВА В КАРДИОЛОГИИVAGUS NERVE STIMULATION IN CARDIOLOGYhttps://orcid.org/0000-0001-8043-501XСыровневВладимир АлександровичSyrovnevVladimir A.

ординатор по курсу «кардиология» 

ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341

residency in cardiology

Akkuratova str. 2, Saint Petersburg, 197341

vsyrovnev@gmail.comЛебедевДмитрий СергеевичLebedevDmitry S.

д.м.н., проф. РАН, руководитель НКО аритмологии 

Prof. of the Russian Academy of Sciences, head of the scientific-advisory department of arrhythmology

lebedevdmitry@mail.ruhttps://orcid.org/0000-0002-6553-9141МихайловЕвгений НиколаевичMikhaylovEvgeny N.

д. м. н., заведующий НИЛ нейромодуляции, доцент кафедры хирургических болезней

MD, associate professor of surgical disease department, head of the scientific research laboratory of neuromodulation

evgenymikhaylov@gmail.com"Федеральный медицинский исследовательский центр имени В. А. Алмазова" Министерства здравоохранения Российской Федерации, Санкт-ПетербургРоссияFederal State Budgetary Institution «Federal Almazov North-West Medical Research Centre» of the Ministry of Health of the Russian Federation.Russian Federation"Федеральный медицинский исследовательский центр имени В. А. Алмазова" Министерства здравоохранения Российской Федерации, Санкт-ПетербургРоссияFederal State Budgetary Institution «Federal Almazov North-West Medical Research Centre» of the Ministry of Health of the Russian FederationRussian Federation20170406201742616Copyright © Сыровнев В.А., Лебедев Д.С., Михайлов Е.Н., 20172017Сыровнев В.А., Лебедев Д.С., Михайлов Е.Н.Syrovnev V.A., Lebedev D.S., Mikhaylov E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/217

В статье проводится обзор ключевых исследований по стимуляции блуждающего нерва в области кардиологии.

Стимуляция блуждающего нерва влияет на нейронные цепи внутренних и наружных сердечных сплетений, усиливающее парасимпатическое влияние. Благодаря такому воздействию в различных экспериментальных и клинических исследованиях достигался положительный терапевтический эффект в лечении наджелудочковых и желудочковых нарушений ритма, сердечной недостаточности, инфаркта миокарда.

Было показано, что стимуляция блуждающего нерва приводит к уменьшению количества эпизодов фибрилляции предсердий, снижает риск возникновения фибрилляции желудочков и обладает протективным эффектом в отношении желудочковых тахикардий. В настоящее время проводятся клинические исследования по стимуляции блуждающего нерва, промежуточные результаты которых отражены в статье.

This article reviews key experimental and clinical studies that have taken place in the field of cardiology.

Vagus nerve stimulation affects neuronal chains of extrinsic and intrinsic cardiac plexuses that enhance the parasimpatic influence. The positive therapeutic effect in the treatment of supraventricular and ventricular rhythm disorders, chronic cardiac failure and myocardial infarction has been achieved in different experimental and clinical trials.

It has been shown that vagus nerve stimulation reduces atrial fibrillation relapse, lowers the risk of ventricular fibrillation and reduces the risk of ventricular tachycardias. After successful pre-clinical studies in congestive heart failure treatment with vagus nerve stimulation, this method started to be investigated in multicenter trials. Their early results are given in the article.

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The authors declare that there are no conflicts of interest present.