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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transmed</journal-id><journal-title-group><journal-title xml:lang="ru">Трансляционная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Translational Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-4495</issn><issn pub-type="epub">2410-5155</issn><publisher><publisher-name>Almazov National Medical Research Centre, Saint Petersburg, Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2311-4495-2014-0-2-97-104</article-id><article-id custom-type="elpub" pub-id-type="custom">transmed-18</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Профилактика инсульта при неклапанной форме фибрилляции предсердий</article-title><trans-title-group xml:lang="en"><trans-title>STROKE PREVENTION IN NON-VALVULAR FORM OF ATRIAL FIBRILLATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>Татьяна Николаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>Tatiana N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Western State Medical University n.a. I.I. Mechnikov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>2</issue><fpage>5</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Новикова Т.Н., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Новикова Т.Н.</copyright-holder><copyright-holder xml:lang="en">Novikova T.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://transmed.almazovcentre.ru/jour/article/view/18">https://transmed.almazovcentre.ru/jour/article/view/18</self-uri><abstract><p>В статье представлен анализ современных подходов к стратификации риска развития ишемического инсульта и системных тромбоэмболий у больных неклапанной формой фибрилляции предсердий, а также риска развития больших кровотечений на фоне антитромботической терапии. Дана сравнительная характеристика новых пероральных антикоагулянтов.</p></abstract><trans-abstract xml:lang="en"><p>The article presents the analysis of modern approaches to risk stratification of development of stroke and systemic thromboembolism in patients with non-valvular atrial fibrillation and also risk stratification of major bleeding on a background of antithrombotic therapy. The comparative characteristic of new oral anticoagulants is given.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>инсульт</kwd><kwd>новые пероральные антикоагулянты</kwd><kwd>atrial fibrillation</kwd><kwd>stroke</kwd><kwd>new oral anticoagulants</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson K.K., Olsen T.S., Dehlendorff C. et al. Hemorrhagic and ischemic strokes compared: stroke severity, mortality, and risk factors // Stroke. - 2009. - Vol. 40. - P. 2068-2072.</mixed-citation><mixed-citation xml:lang="en">Anderson K.K., Olsen T.S., Dehlendorff C. et al. Hemorrhagic and ischemic strokes compared: stroke severity, mortality, and risk factors // Stroke. - 2009. - Vol. 40. - P. 2068-2072.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Savelieva I., Bajpai A., Camm A.J. Stroke in atrial fibrillation: update on pathophysiology, new antithrombotic therapies, and evolution of procedures and devices // Ann. Med. - 2007. - Vol. 39. - P. 71-91.</mixed-citation><mixed-citation xml:lang="en">Savelieva I., Bajpai A., Camm A.J. Stroke in atrial fibrillation: update on pathophysiology, new antithrombotic therapies, and evolution of procedures and devices // Ann. Med. - 2007. - Vol. 39. - P. 71-91.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Emmerich J., Heuzey J.-Y.L., Bath P.M.W., Connolly S.J. Indication for antithrombotic therapy for atrial fibrillation: reconciling the guidelines with clinical practice. // Eur. Heart. J. - 2005. - Vol. 7, Supp. C. - P. C28-C33.</mixed-citation><mixed-citation xml:lang="en">Emmerich J., Heuzey J.-Y.L., Bath P.M.W., Connolly S.J. Indication for antithrombotic therapy for atrial fibrillation: reconciling the guidelines with clinical practice. // Eur. Heart. J. - 2005. - Vol. 7, Supp. C. - P. C28-C33.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hannon N., Sheehan O., Kelly L. et al. Stroke associated with atrial fibrillation incidence and early outcomes in the north Dublin population stroke study // Cerebrovasc. Dis. - 2010. - Vol. 29. - P. 43-49.</mixed-citation><mixed-citation xml:lang="en">Hannon N., Sheehan O., Kelly L. et al. Stroke associated with atrial fibrillation incidence and early outcomes in the north Dublin population stroke study // Cerebrovasc. Dis. - 2010. - Vol. 29. - P. 43-49.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gladstone D.J., Bui E., Fang J. et al. Potentially Preventable Strokes in High-Risk Patients With Atrial Fibrillation Who Are Not Adequately Anticoagulated // Stroke. - 2009. - Vol. 40. - P. 235-240.</mixed-citation><mixed-citation xml:lang="en">Gladstone D.J., Bui E., Fang J. et al. Potentially Preventable Strokes in High-Risk Patients With Atrial Fibrillation Who Are Not Adequately Anticoagulated // Stroke. - 2009. - Vol. 40. - P. 235-240.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hart R.G., Pearce L.A., Rothbart R.M. et al. Stroke With Intermittent Atrial Fibrillation: Incidence and Predictors During Aspirin Therapy // J. Am. Coll. Cardiol. - 2000. - Vol. 35. - P. 183-187.</mixed-citation><mixed-citation xml:lang="en">Hart R.G., Pearce L.A., Rothbart R.M. et al. Stroke With Intermittent Atrial Fibrillation: Incidence and Predictors During Aspirin Therapy // J. Am. Coll. Cardiol. - 2000. - Vol. 35. - P. 183-187.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Flaker G.C., Belew K., Beckman K. and the AFFIRM Investigators. Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study // Am. Heart J. - 2005. - Vol. 149. - P. 657-663.</mixed-citation><mixed-citation xml:lang="en">Flaker G.C., Belew K., Beckman K. and the AFFIRM Investigators. Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study // Am. Heart J. - 2005. - Vol. 149. - P. 657-663.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Сулимов В.А., Голицин С.П., Панченко Е.П. и соавт. Диагностика и лечение фибрилляции предсердий. Рекомендации ВНОК и ВНОА, 2011 // Рациональная фармакотерапия в кардиологии. - 2011. - Т. 7, № 4, приложение. - С. 3-79.</mixed-citation><mixed-citation xml:lang="en">Сулимов В.А., Голицин С.П., Панченко Е.П. и соавт. Диагностика и лечение фибрилляции предсердий. Рекомендации ВНОК и ВНОА, 2011 // Рациональная фармакотерапия в кардиологии. - 2011. - Т. 7, № 4, приложение. - С. 3-79.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Сулимов В.А., Голицин С.П., Панченко Е.П. и соавт. Диагностика и лечение фибрилляции предсердий // Рекомендации РКО, ВНОА и АССХ. - М., 2012. - 100 с.</mixed-citation><mixed-citation xml:lang="en">Сулимов В.А., Голицин С.П., Панченко Е.П. и соавт. Диагностика и лечение фибрилляции предсердий // Рекомендации РКО, ВНОА и АССХ. - М., 2012. - 100 с.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Camm A.J., Kirchhof P., Lip G.Y. et al. Guidelines for the management of atrial fibrillation // Europ. Heart J. - 2010. - Vol. 31. - P. 2369-2429.</mixed-citation><mixed-citation xml:lang="en">Camm A.J., Kirchhof P., Lip G.Y. et al. Guidelines for the management of atrial fibrillation // Europ. Heart J. - 2010. - Vol. 31. - P. 2369-2429.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Camm A.J., Lip G.Y., De Caterina R. et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation // Europ. Heart J. - 2012. - [Электронный ресурс] doi:10.1093/eurheartj/ehs253</mixed-citation><mixed-citation xml:lang="en">Camm A.J., Lip G.Y., De Caterina R. et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation // Europ. Heart J. - 2012. - [Электронный ресурс] doi:10.1093/eurheartj/ehs253</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lip G.Y., Nieuwlaat R., Pisters R. et al. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factorbased approach: the Euro Heart Survey on atrial fibrillation // Chest. - 2010. - Vol. 137. - P. 263-272.</mixed-citation><mixed-citation xml:lang="en">Lip G.Y., Nieuwlaat R., Pisters R. et al. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factorbased approach: the Euro Heart Survey on atrial fibrillation // Chest. - 2010. - Vol. 137. - P. 263-272.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Connolly S.J., Eikelboom J., Joyner C. et al. Apixa-ban in Patients with Atrial Fibrillation // N. Engl. J. Med. - 2011. - Vol. 364. - P. 806-817.</mixed-citation><mixed-citation xml:lang="en">Connolly S.J., Eikelboom J., Joyner C. et al. Apixa-ban in Patients with Atrial Fibrillation // N. Engl. J. Med. - 2011. - Vol. 364. - P. 806-817.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Connolly S.J., Eikelboom J., Hirsh J. et al. ACTIVE (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events) Steering Committee and Investigators. Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable // Ann. Intern. Med. - 2011. - Vol. 155. - P. 579-586.</mixed-citation><mixed-citation xml:lang="en">Connolly S.J., Eikelboom J., Hirsh J. et al. ACTIVE (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events) Steering Committee and Investigators. Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable // Ann. Intern. Med. - 2011. - Vol. 155. - P. 579-586.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Link K.P. The discovery of dicumarol and its sequels // Circulation. - 1959. - Vol. 19. - P. 97-107.</mixed-citation><mixed-citation xml:lang="en">Link K.P. The discovery of dicumarol and its sequels // Circulation. - 1959. - Vol. 19. - P. 97-107.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hart R.G., Pearce L.A., Aguilar M.I. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have non-valvular atrial fibrillation // Ann. Intern. Med. - 2007. - Vol. 146. - P. 857-867.</mixed-citation><mixed-citation xml:lang="en">Hart R.G., Pearce L.A., Aguilar M.I. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have non-valvular atrial fibrillation // Ann. Intern. Med. - 2007. - Vol. 146. - P. 857-867.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Connolly S.J., Pogue J., Hart A. et al. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controllled trial // Lancet. - 2006. - Vol. 367. - P. 1903-1912.</mixed-citation><mixed-citation xml:lang="en">Connolly S.J., Pogue J., Hart A. et al. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controllled trial // Lancet. - 2006. - Vol. 367. - P. 1903-1912.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Connolly S.J., Ezekowitz M.D., Yusuf S. et al. Dabigatran versus Warfarin in Patients with Atrial Fibrillation // N. Engl. J. Med. - 2009. - Vol. 361. - P. 1139-1151.</mixed-citation><mixed-citation xml:lang="en">Connolly S.J., Ezekowitz M.D., Yusuf S. et al. Dabigatran versus Warfarin in Patients with Atrial Fibrillation // N. Engl. J. Med. - 2009. - Vol. 361. - P. 1139-1151.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">ROCKET AF Study Investigators. Rivaroxaban - once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study // Am. Heart J. - 2010. - Vol. 159. - P. 340-347.</mixed-citation><mixed-citation xml:lang="en">ROCKET AF Study Investigators. Rivaroxaban - once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study // Am. Heart J. - 2010. - Vol. 159. - P. 340-347.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Patel M.R., Mahaffey K.W., Garg J. et al. ROCKET AF Investigators. Rivaroxaban versus warfarin in non-valvular atrial fibrillation // N. Engl. J. Med. - 2011. - Vol. 365. - P. 883-891.</mixed-citation><mixed-citation xml:lang="en">Patel M.R., Mahaffey K.W., Garg J. et al. ROCKET AF Investigators. Rivaroxaban versus warfarin in non-valvular atrial fibrillation // N. Engl. J. Med. - 2011. - Vol. 365. - P. 883-891.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Granger C.B., Alexander J.H., McMurray J.J. et al. ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation // N. Engl. J. Med. - 2011. - Vol. 365, № 11. - P. 981.</mixed-citation><mixed-citation xml:lang="en">Granger C.B., Alexander J.H., McMurray J.J. et al. ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation // N. Engl. J. Med. - 2011. - Vol. 365, № 11. - P. 981.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Heidbuchel H., Verhamme P., Alings M. et al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation // Europace. - 2013. - Vol. 15. - P. 625-651. - [Электронный ресурс] doi:10.1093/europace/eut083</mixed-citation><mixed-citation xml:lang="en">Heidbuchel H., Verhamme P., Alings M. et al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation // Europace. - 2013. - Vol. 15. - P. 625-651. - [Электронный ресурс] doi:10.1093/europace/eut083</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
