transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2016-3-1-50-62transmed-164Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯEXPERIMENTAL STUDIESКАРДИОПРОТЕКТИВНЫЕ ЭФФЕКТЫ ИШЕМИЧЕСКОГО КОНДИЦИОНИРОВАНИЯ: СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МЕХАНИЗМАХ, ЭКСПЕРИМЕНТАЛЬНЫЕ ПОДТВЕРЖДЕНИЯ, КЛИНИЧЕСКАЯ РЕАЛИЗАЦИЯCARDIOPROTECTIVE EFFECTS OF ISCHEMIC CONDITIONING. UP-TO-DATE INFORMATION IN PHYSIOLOGY, EXPERIMENTAL EVIDENCES AND CLINICAL APPLICATIONSБаутинАндрей ЕвгеньевичBautinA. E.abautin@mail.ruКарповаЛюдмила ИгоревнаKarpovaL. I.noemail@neicon.ruМаричевАлександр ОлеговичMarichevA. O.noemail@neicon.ruТашхановДмитрий МаратовичTashkhanovD. M.noemail@neicon.ruНауменкоВиталий СергеевичNaumenkoV. S.noemail@neicon.ruГалагудзаМихаил МихайловичGalagudzaM. M.noemail@neicon.ruСеверо-Западный Федеральный медицинский исследовательский центр им. В.А. АлмазоваРоссияFederal Almazov North-West Medical Research CentreRussian Federation201623122016315062Copyright © Баутин А.Е., Карпова Л.И., Маричев А.О., Ташханов Д.М., Науменко В.С., Галагудза М.М., 20162016Баутин А.Е., Карпова Л.И., Маричев А.О., Ташханов Д.М., Науменко В.С., Галагудза М.М.Bautin A.E., Karpova L.I., Marichev A.O., Tashkhanov D.M., Naumenko V.S., Galagudza M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/164

Ишемическое кондиционирование предполагает индукцию органопротекции при выполнении коротких эпизодов ишемии-реперфузии до или после основного события ишемии. В обзоре рассматриваются современные представления о механизмах развития кардиопротективного действия различных вариантов этой нефармакологической методики, представлены экспериментальные данные, подтверждающие ее эффективность. Кроме того, в статье приведен анализ результатов клинических исследований применения ишемического кондиционирования в различных областях кардиохирургии.

Ischemic conditioning has been applied before or after an ischemic insult to the myocardium and has taken the form of local induction of ischemia or ischemia of distant tissues. The aim of this article is to review the up-to-date information in physiological mechanism of ischemic conditioning and experimental evidences of it cardioprotective effects. Additionally, the review discusses the results of recent clinical trials of different types of ischemic preconditioning.

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The authors declare that there are no conflicts of interest present.