References

transmed

Трансляционная медицина

Translational Medicine

2311-44952410-5155

Almazov National Medical Research Centre, Saint Petersburg, Russia

10.18705/2311-4495-2016-3-1-39-42

transmed-162

Research Article

РЕВМАТОЛОГИЯ

RHEUMATOLOGY

ВИТАМИН D И ОСТЕОАРТРОЗ

VITAMIN D AND OSTEOARTHRITIS

Баженов

Александр Николаевич

Bazhenov

A. N.

bazhenov@almazovcentre.ru

Северо-Западный Федеральный медицинский исследовательский центр им. В. А. АлмазоваРоссияFederal Almazov North-West Medical Research CentreRussian Federation

2016

23122016

313942

2016

Баженов А.Н.

Bazhenov A.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://transmed.almazovcentre.ru/jour/article/view/162

В статье обсуждается возможная роль дефицита витамина D в прогрессировании остеоартроза (ОА). Уделено внимание роли витамина D в изменении архитектоники суставного хряща, влиянии на медиаторы воспаления и др. Эти сведения могут иметь значение для разработки новых подходов к профилактике прогрессирования ОА.

The paper discusses the possible role of vitamin D in the progression of osteoarthritis (OA). Emphasis is placed on the role of vitamin D in a change in the architectonics of the articulate cartilage, inflammatory mediators, etc. These information may be of importance for elaborating new approaches to OA to the preventive maintenance of the progression.

остеоартрозвитамин D25(OH)Dсуставной хрящosteoarthritisvitamin D25(OH)Darticulate cartilage

References1

Zhang F.F, Driban J.B, Lo G.H, Price L.L, Booth S, Eaton C.B, Lu B, Nevitt M, Jackson B, Garganta C, Hochberg M.C, Kwoh K, McAlindon T.E. Vitamin D deficiency is associated with progression of knee osteoarthritis. J. Nutr. 2014; 144(12): 2002-2008.

Lanyon P, Muir K, Doherty S, Doherty M. Assessment of a genetic contribution to osteoarthritis of the hip: sibling study. BMJ. 2000; 321(7270): 1179-1183.

Das S.K, Farooqi A. Osteoarthritis. Best Pract Res Clin Rheumatol. 2008; 22(4): 657-675.

Sanchez C, Deberg M.A, Bellahcllne A, et al. Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone. Arthritis Rheum. 2008; 58(2): 442-455.

Chan T.F, Couchourel D, Abed E, et al. Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts. J Bone Mineral Res. 2011; 26(7): 1399-1410.

Lajeunesse D, Reboul P. Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling. Curr Opin Rheumatol. 2003; 15(5): 628-633.

Prasadam I, van Gennip S, Friis T, et al. ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts. Arthritis Rheum. 2010; 62(5): 1349-1360.

Manolagas S.C. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. EndocrRev. 2000; 21(2): 115-137.

Pacifici R. Role of T cells in ovariectomy induced bone loss-revisited. J Bone Miner Res. 2012; 27(2): 231-239.

Hu Y, Liu Y, Lajeunesse D, Mainard D, Jouzeau J.Y, Reboul P. Identification of two populations of osteoarthritic osteoblasts according to the 1,25[OH]2 vitamin D3 potency to stimulate osteocalcin. Biomed Mater Eng. 2015; 25(1 Suppl):103-110.

Sanghi D, Mishra A, Sharma A.C, Raj S, Mishra R, Kumari R, Natu S.M, Agarwal S, Srivastava R.N. Elucidation of dietary risk factors in osteoarthritis knee-a case-control study. J Am Coll Nutr. 2015; 34(1): 15-20.

Konstari S, Kaila-Kangas L, Jääskeläinen T, Heliövaara M, Rissanen H, Marniemi J, Knekt P, Arokoski J, Karppinen J. Serum 25-hydroxyvitamin D and the risk of knee and hip osteoarthritis leading to hospitalization: a cohort study of 5274 Finns. Rheumatology (Oxford). 2014; 53(10): 1778-1782.

Felson D.T, Niu J, Clancy M, Aliabadi P, Sack B, Guermazi A, Hunter D.J., Amin S, Rogers G, Booth S.L. Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies. Arthritis Rheum. 2007; 56(1): 129136.

Cao Y, Jones G, Cicuttini F, Winzenberg T, Wluka A, Sharman J, Nguo K, Ding C. Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial. Trials. 2012; 13: 131.

McAlindon T.E, Felson D.T, Zhang Y, Hannan M.T, Aliabadi P, Weissman B, Rush D, Wilson P.W, Jacques P. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med. 1996; 125(5): 353-359.

Wang X, Hunter D, xu J, Ding C. Metabolic triggered inflammation in osteoarthritis. Osteoarthritis Cartilage. 2015; 23(1): 22-30.

Barker T, Henriksen V.T, Rogers V.E, Aguirre D, Trawick R.H, Lynn Rasmussen G, Momberger N.G. Vitamin D deficiency associates with y-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis. Redox Biol. 2014; 2:466-474.

Laslett L.L, Quinn S, Burgess J.R, Parameswaran V, Winzenberg T.M, Jones G, Ding C. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study. Ann Rheum Dis. 2014; 73(4): 697-703.

Glover T.L, Goodin B.R, Horgas A.L, Kindler L.L, King C.D, Sibille K.T, Peloquin C.A, Riley J.L 3rd, Staud R, Bradley L.A, Fillingim R.B. Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis. Arthritis Rheum. 2012; 64(12): 3926-3935.

Glover T.L, Goodin B.R, King C.D, Sibille K.T, Herbert M.S, Sotolongo A.S, Cruz-Almeida Y, Bartley E.J, Bulls H.W, Horgas A.L, Redden D.T, Riley J.L. 3rd, Staud R, Fessler B.J, Bradley L.A, Fillingim R.B. A Cross-Sectional Examination of Vitamin D, Obesity, and Measures of Pain and Function in Middle-Aged and Older Adults with Knee Osteoarthritis. Clin J Pain. 2015. [Epub ahead of print].

Malas F.U, Kara M, Aktekin L, Ersöz M, Ozçakar L. Does vitamin D affect femoral cartilage thickness? An ultrasonographic study. Clin Rheumatol. 2014; 33(9): 1331-1334.

Al-Jarallah K.F, Shehab D, Al-Awadhi A, Nahar I, Haider M.Z, Moussa M.A. Are 25(OH)D levels related to the severity of knee osteoarthritis and function? Med Princ Pract. 2012; 21(1): 74-78.

Grazio S, Naglic B.B, Anic B, Grubisic F, Bobek D, Bakula M, Kavanagh H.S, Kuna A.T, Cvijetic S. Vitamin D serum level, disease activity and functional ability in different rheumatic patients. Am J Med Sci. 2015; 349(1): 46-49.

Баженов А.Н., Плесовских И.В., Илюшина Л.В., Баженова О.П. Применение препаратов кальция и витамина D у стероидозависимых больных ревматоидным артритом (статья). Российский медицинский журнал. 2008; 1: 13-15.

Плесовская И.В., Илюшина Л.В., Баженов А.Н. Препараты нативного и активного витаминов D у больных гормонозависимым ревматоидным артритом. Артериальная гипертензия. 2008; 14 (1): 123-126

Barker T, Martins T.B, Hill H.R, Kjeldsberg C.R, Dixon B.M, Schneider E.D, Henriksen V.T, Weaver L.K. Vitamin D sufficiency associates with an increase in antiinflammatory cytokines after intense exercise in humans. Cytokine. 2014; 65(2): 134-137.

Sanghi D, Mishra A, Sharma A.C, Singh A, Natu S.M, Agarwal S, Srivastava R.N. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013; 471(11): 3556-3562.

Sakalli H, Arslan D, Yucel A.E. The effect of oral and parenteral vitamin D supplementation in the elderly: a prospective, double-blinded, randomized, placebo-controlled study. Rheumatol. Int. 2012; 32(8): 2279-2283.

McAlindon T, LaValley M, Schneider E, Nuite M, Lee J.Y, Price L.L, Lo G, Dawson-Hughes B. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013; 309(2): 155-162.

The authors declare that there are no conflicts of interest present.