transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2016-3-1-6-20transmed-158Research ArticleКАРДИОЛОГИЯCARDIOLOGYАНЕВРИЗМА ВОСХОДЯЩЕГО ОТДЕЛА АОРТЫ: ОТ МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИХ ОСОБЕННОСТЕЙ ПАТОГЕНЕЗА ДО ВЫБОРА МЕТОДА ЛЕЧЕНИЯASCENDING AORTIC ANEURYSM: FROM MOLECULAR AND GENETIC FEATURES OF PATHOGENESIS TO TREATMENT OPTIONSГаврилюкНаталья ДмитриевнаGavriliukN. D.Gavrilyuk_ND@almazovcentre.ruУспенскийВладимир ЕвгеньевичUspenskiyV. E.noemail@neicon.ruМалашичеваАнна БорисовнаMalashichevaA. B.noemail@neicon.ruИртюгаОльга БорисовнаIrtyugaO. B.noemail@neicon.ruДружковаТатьяна АлександровнаDruzhkovaT. A.noemail@neicon.ruКостинаДарья АлексеевнаKostinaD. A.noemail@neicon.ruВоронкинаИрина ВладимировнаVoronkinaI. V.noemail@neicon.ruЖлобаАлександр АнатольевичZhlobaA. A.noemail@neicon.ruЖуковВладимир АлександровичZhukovV. A.noemail@neicon.ruЖернаковАлександр ИгоревичZhernakovA. I.noemail@neicon.ruИбрагимовАмир НасировичIbragimovA. N.noemail@neicon.ruМоисееваОльга МихайловнаMoiseevaO. M.noemail@neicon.ruГордеевМихаил ЛеонидовичGordeevM. L.noemail@neicon.ruФедеральное государственное бюджетное учреждение «Северо-Западный Федеральный медицинский исследовательский центр им. В. А. Алмазова» Минздрава РоссииРоссияFederal Almazov North-West Medical Research CentreRussian FederationФедеральное государственное бюджетное учреждение «Северо-Западный Федеральный медицинский исследовательский центр им. В. А. Алмазова» Минздрава России; Санкт-Петербургский Государственный УниверситетРоссияFederal Almazov North-West Medical Research Centre; Saint Petersburg UniversityRussian FederationФедеральное государственное бюджетное научное учреждение «институт цитологии»РоссияInstitute of Cytology of the Russian Academy of ScienceRussian FederationФедеральное государственное бюджетное учреждение «Северо-Западный Федеральный медицинский исследовательский центр им. В. А. Алмазова» Минздрава России; Первый Санкт-Петербургский государственный медицинский университет им. акад. и. П. ПавловаРоссияFederal Almazov North-West Medical Research Centre; Pavlov First Saint Petersburg State Medical UniversityRussian FederationФедеральное государственное бюджетное учреждение «Северо-Западный Федеральный медицинский исследовательский центр им. В. А. Алмазова» Минздрава России; Всероссийский научно-исследовательский институт сельскохозяйственной микробиологииРоссияFederal Almazov North-West Medical Research Centre; Pavlov First Saint Petersburg State Medical University; All-Russian Research Institute for Agricultural MicrobiologyRussian FederationФедеральное государственное бюджетное учреждение «Северо-Западный Федеральный медицинский исследовательский центр им. В. А. Алмазова» Минздрава России; Всероссийский научно-исследовательский институт сельскохозяйственной микробиологииРоссияFederal Almazov North-West Medical Research Centre; All-Russian Research Institute for Agricultural MicrobiologyRussian Federation20162312201631620Copyright © Гаврилюк Н.Д., Успенский В.Е., Малашичева А.Б., Иртюга О.Б., Дружкова Т.А., Костина Д.А., Воронкина И.В., Жлоба А.А., Жуков В.А., Жернаков А.И., Ибрагимов А.Н., Моисеева О.М., Гордеев М.Л., 20162016Гаврилюк Н.Д., Успенский В.Е., Малашичева А.Б., Иртюга О.Б., Дружкова Т.А., Костина Д.А., Воронкина И.В., Жлоба А.А., Жуков В.А., Жернаков А.И., Ибрагимов А.Н., Моисеева О.М., Гордеев М.Л.Gavriliuk N.D., Uspenskiy V.E., Malashicheva A.B., Irtyuga O.B., Druzhkova T.A., Kostina D.A., Voronkina I.V., Zhloba A.A., Zhukov V.A., Zhernakov A.I., Ibragimov A.N., Moiseeva O.M., Gordeev M.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/158

Аневризма восходящего отдела аорты - грозное заболевание, занимающее 15-е место среди всех причин внезапной смерти. Социальная значимость патологии и ее зачастую полная бессимптомность до развития жизнеугрожающих осложнений диктует необходимость ранней диагностики и своевременного начала лечения. В данном обзоре объединены наиболее активно обсуждаемые в последнее время теории формирования аневризм восходящего отдела аорты. Кроме того, представлены результаты исследований, проводимых на базе СЗФМИЦ имени В. А. Алмазова с 2006 года, которые демонстрируют роль мультидисциплинарного подхода к изучению и лечению аневризм восходящего отдела аорты.

Ascending aortic aneurysm is a dangerous disease ranking 15th place among all causes of sudden death. The social significance of this disease and its almost complete asymptomatic character before life-threatening complications occur determine importance of its early detection and timely treatment. This review joins the most discussed recent theories of the formation of an ascending aortic aneurysm. The own data of the Federal Almazov North-West Medical Research Centre are also presented. Multidisciplinary approach of management and research of ascending aortic aneurysms is used in the Almazov Centre since 2006.

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The authors declare that there are no conflicts of interest present.