transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2026-13-4-322-338transmed-1213Research ArticleСЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯCARDIOVASCULAR MEDICINEОсобенности диагностики и тактики ведения пациентов с кардиогенным саркоидозом (обзор литературы и клинические случаи)Specifics of diagnosis and management of patients with cardiac sarcoidosis (literature review and clinical cases)https://orcid.org/0000-0002-9023-6986СтаршиноваА. А.StarshinovaA. A.

Старшинова Анна Андреевна, д-р мед. наук, гл. науч.cотр. лаборатории, начальник Управления научными исследованиями, профессор кафедры факультетской терапии с клиникой

Cанкт-Петербург

Anna A. Starshinova, MD, DSc, Chief Researcher of the Laboratory, Head of the Research Department, Professor of the Department of Faculty Therapy with a Clinic 

St. Petersburg 

starshinova_777@mail.ruhttps://orcid.org/0000-0002-7452-1971ФедотовП. А.FedotovP. A.

Федотов Петр Алексеевич, канд. мед. наук, ведущий науч. сотр., заведующий НИЛ высокотехнологичных методов лечения сердечной недостаточности, доцент кафедры факультетской терапии с клиникой

Cанкт-Петербург

Petr A. Fedotov, MD, PhD, Leading Researcher and Head Research Laboratory, Associate Professor of the Department of Faculty Therapy with aClinic

St. Petersburg  

drheart@mail.ruhttps://orcid.org/0000-0002-7074-0675МусаеваБ. Б.MusaevaB. B.

Мусаева Булгун Бадмаевна, лаборант-исследователь 

Cанкт-Петербург 

Bulgun B. Musaeva, MD, Researcher of the Research Laboratory 

St. Petersburg 

bulgun_musaeva@mail.ruhttps://orcid.org/0009-0007-0743-3254МироноваЕ. С.MironovaE. S.

Миронова Елена Сергеевна, ординатор 

Уфа 

Elena S. Mironova, Second-year resident  

Ufa 

lenikmir@mail.ruhttps://orcid.org/0000-0002-4201-4537СабироваА. Р.SabirovaA. R.

Сабирова Адиля Радиковна, ассистент кафедры фтизиатрии, инженер-исследователь лаборатории 

Cанкт-Петербург 

Adila R. Sabirova, Assistant Professor, Research Engineer at the “Probabilistic Methods in Analysis” Laboratory 

Ufa, St. Petersburg 

adilyasabirova@mail.ruhttps://orcid.org/0000-0002-7720-4832ШариповР. А.SharipovR. A.

Шарипов Рауль Ахнафович, канд. мед. наук, заведующий кафедрой фтизиатрии

 Уфа 

Raul A. Sharipov, MD, PhD, Head of the Department of Phthisiology at the Bashkir State Medical University 

Ufa 

raul-crkb@yandex.ruhttps://orcid.org/0000-0003-1878-4467КудлайД. А.KudlayD. A.

Кудлай Дмитрий Анатольевич, член-корр. РАН, д-р мед. наук, профессор кафедры фармакологии, профессор кафедры фармакогнозии и промышленной фармации, ведущий науч. сотр. лаборатории персонализированной медицины и молекулярной иммунологии 

Москва

Dmitry A. Kudlay, Corresponding member of the Russian Academy of Sciences, MD, DSc, Professor of the Department of Pharmacology, Professor of the Department of Pharmacognosy and Industrial Pharmacy 

Moscow 

D624254@gmail.comhttps://orcid.org/0000-0003-2929-0980ШляхтоЕ. В.ShlyakhtoE. V.

Шляхто Евгений Владимирович, д-р мед. наук, академик РАН, генеральный директор ФГБУ «НМИЦ им. В. А. Алмазова» Минздрава России 

Санкт-Петербург

Evgeny V. Shlyakhto, MD, DSc, Academician of the RAS, General Director of V. A. Almazov NMRC 

St. Petersburg 

shlyakhto@almazovcentre.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный университет»РоссияFederal State Budgetary Institution “V. A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation; Saint Petersburg State UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный университет»РоссияSaint Petersburg State UniversityRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Башкирский государственный медицинский университет»РоссияFederal State Budgetary Institution “V. A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation; Saint Petersburg State UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of the Ministry of Health of RussiaRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный университет»; Федеральное государственное бюджетное образовательное учреждение высшего образования «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSaint Petersburg State University; Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of the Ministry of Health of RussiaRussian FederationФедеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И. М. Сеченова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное учреждение «Государственный научный центр “Институт иммунологии” Федерального медико-биологического агентства»; Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М. В. Ломоносова»РоссияFederal State Autonomous Educational Institution of Higher Education “First Moscow State Medical University named after I. M. Sechenov” of the Ministry of Health of Russia; Federal State Budgetary Institution “State Scientific Center ‘Institute of Immunology’ Federal Medical-Biological Agency”; Federal State Budgetary Educational Institution of Higher Education “Lomonosov Moscow State University”Russian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Institution “V. A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian FederationRussian Federation202611102026134322338Copyright © Старшинова А.А., Федотов П.А., Мусаева Б.Б., Миронова Е.С., Сабирова А.Р., Шарипов Р.А., Кудлай Д.А., Шляхто Е.В., 20262026Старшинова А.А., Федотов П.А., Мусаева Б.Б., Миронова Е.С., Сабирова А.Р., Шарипов Р.А., Кудлай Д.А., Шляхто Е.В.Starshinova A.A., Fedotov P.A., Musaeva B.B., Mironova E.S., Sabirova A.R., Sharipov R.A., Kudlay D.A., Shlyakhto E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/1213

Диагностика саркоидоза сердца остается сложной задачей и требует проведения дифференциального поиска с исключением других возможных причин патологических изменений. Трудности в диагностике обусловлены отсутствием известных причин заболевания, а также неспецифичностью клинических проявлений. Целью представленного обзора явился анализ данных за последние десять лет, касающихся диагностики саркоидоза сердца. Материалы и методы: статья представляет собой обзор современной литературы, посвященной диагностике саркоидоза сердца. Поиск публикаций проводился в международных и отечественных электронных базах данных PubMed, Scopus, Web of Science, Google Scholar и eLIBRARY. RU. Использовались следующие ключевые слова и их комбинации на английском и русском языках: cardiac sarcoidosis, sarcoidosis of the heart, cardiac sarcoidosis, heart transplantation for sarcoidosis, diagnosis of sarcoidosis, саркоидоз сердца, кардиальный саркоидоз, трансплантация сердца при саркоидозе, диагностика саркоидоза. Результаты. В обзор включались публикации преимущественно за 2016–2026 гг., а также более ранние фундаментальные исследования и международные клинические рекомендации, имеющие ключевое значение для понимания проблемы. Отбирались систематические обзоры, метаанализы, клинические рекомендации профессиональных сообществ, проспективные и ретроспективные исследования, а также крупные регистры пациентов, посвященные диагностике, лечению и прогнозу саркоидоза сердца. Заключение: в данном обзоре сделан акцент на современных методах диагностики и тактике ведения пациентов с саркоидозом сердца, который представляет собой одно из наиболее тяжелых и неблагоприятных с прогностической точки зрения проявлений системного саркоидоза. Его диагностика часто задерживается из-за неспецифических симптомов и очагового распределения гранулематозного воспаления в миокарде. Представленные клинические случаи наглядно демонстрируют возможности современной диагностики и лечения пациентов с саркоидозом сердца.

Cardiac sarcoidosis remains a diagnostic challenge and requires differential diagnosis to exclude other potential causes of pathological changes. Difficulties in diagnosis stem from the unknown aetiology of the disease, as well as the non-specific nature of its clinical manifestations. The aim of this review is to analyse data published over the last decade concerning the diagnosis of cardiac sarcoidosis. Materials and Methods. This article presents a narrative review of contemporary literature on the diagnosis of cardiac sarcoidosis. A search for publications was conducted across international and domestic electronic databases, including PubMed, Scopus, Web of Science, Google Scholar, and eLIBRARY.RU. The following keywords and their combinations were used in both English and Russian: cardiac sarcoidosis, heart transplantation for sarcoidosis, diagnosis of sarcoidosis. Results. The review predominantly includes publications from 2016–2026, alongside earlier fundamental studies and international clinical guidelines that are pivotal for understanding the issue. Selection criteria encompassed systematic reviews, meta-analyses, professional society clinical guidelines, prospective and retrospective cohort studies, and large patient registries dedicated to the diagnosis, management, and prognosis of cardiac sarcoidosis. Conclusion: This review focuses on modern diagnostic modalities and the management strategy for patients with cardiac sarcoidosis, which represents one of the most severe and prognostically unfavourable manifestations of systemic sarcoidosis. Diagnosis is frequently delayed due to non-specific symptoms and the patchy distribution of granulomatous inflammation within the myocardium. Presented case reports clearly demonstrate the capabilities of contemporary diagnostics and treatment strategies for patients with cardiac sarcoidosis.

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The authors declare that there are no conflicts of interest present.