transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2025-12-4-352-372LWVIOUtransmed-1063Research ArticleНАНОТЕХНОЛОГИИNANOTECHNOLOGYТаргетная доставка антиоксидантов в миокард с помощью наноразмерных носителей: современный подход к уменьшению ишемическиреперфузионного поврежденияTargeted delivery of antioxidants to the myocardium using nanoscale carriers: a modern approach to reducing ischemic-reperfusion injuryhttps://orcid.org/0000-0002-1896-5703ЧебуркинЮ. В.CheburkinYu. V.

Чебуркин Юрий Владимирович — кандидат медицинских наук, заведующий НИЛ инфекционных патогенов и биомолекулярных наноструктур

Санкт-Петербург 

Yuri V. Cheburkin, MD, PhD, Head of the Research Laboratory of Infectious Pathogens and Biomolecular Nanostructures

Saint Petersburg 

cheburkin_yuv@almazovcentre.ruСмирновЕ. А.SmirnovE. A.

Смирнов Евгений Алексеевич — младший научный сотрудник НИЛ инфекционных патогенов и биомолекулярных наноструктур; магистрант 

Санкт-Петербург 

Evgeny A. Smirnov, Junior Researcher of the Research Laboratory of Infectious Pathogens and Biomolecular Nanostructures; Postgraduate Student

Saint Petersburg 

sea222777@yandex.ruМурашкоЕ. А.MurashkoE. A.

Мурашко Екатерина Александровна — кандидат химических наук, заведующий НИЛ метаболомного и метаболического профилирования, ассистент кафедры химии Института медицинского образования

Санкт-Петербург 

Ekaterina A. Murashko, PhD, Head of the Research Laboratory of Metabolomic and Metabolic Profiling; Assistant of the Department of Chemistry, Institute of Medical Education

Saint Petersburg 

murashko_ea@almazovcentre.ruКоролевД. В.KorolevD. V.

Королев Дмитрий Владимирович — доктор химических наук, доцент, заведующий НИЛ нанотехнологий, научный сотрудник лаборатории биофизики кровообращения Института сердечно-сосудистых заболеваний

Санкт-Петербург 

Dmitry V. Korolev, DSc, Associate Professor, Head of the Research Laboratory of Nanotechnologies; Researcher of the Laboratory of Circulatory Biophysics, Institute of Cardiovascular Diseases

Saint Petersburg 

dimon@cardioprotect.spb.ruКолобовА. А.KolobovA. A.

Колобов Алексей Александрович — кандидат биологических наук, ведущий научный сотрудник лаборатории химии пептидов

Санкт-Петербург 

Alexey A. Kolobov, PhD of Biological Sciences, Leading Researcher of the Laboratory of Peptide Chemistry

Saint Petersburg 

alexey.kolobov.spb@gmail.comБуткоД. Ю.ButkoD. Yu.

Бутко Дмитрий Юрьевич — доктор медицинских наук, профессор, заведующий кафедрой медицинской реабилитации и спортивной медицины

Санкт-Петербург 

Dmitry Yu. Butko, MD, DSc, Professor, Head of the Department of Medical Rehabilitation and Sports Medicine

Saint Petersburg 

prof.butko@mail.ruСитковН. О.SitkovN. O.

Ситков Никита Олегович — кандидат технических наук, ведущий научный сотрудник НИЛ инфекционных патогенов и биомолекулярных наноструктур, доцент кафедры микро- и наноэлектроники

Санкт-Петербург 

Nikita O. Sitkov, PhD, Leading Researcher of the Research Laboratory of Infectious Pathogens and Biomolecular Nanostructures; Associate Professor of the Department of Micro- and Nanoelectronics

Saint Petersburg 

sitkov93@yandex.ruГалагудзаМ. М.GalagudzaMi. M.

Галагудза Михаил Михайлович — доктор медицинских наук, член-корреспондент РАН, директор Института экспериментальной медицины и заведующий кафедрой патологической физиологии Института медицинского образования, главный научный сотрудник

пр. Пархоменко, д. 15, лит. Б, Санкт-Петербург, 194156 

Mikhail M. Galagudza, MD, DSc, Corresponding Member of the Russian Academy of Sciences, Director of the Institute of Experimental Medicine and Head of the Department of Pathological Physiology, Institute of Medical Education; Principal Researcher

Parkhomenko str., 15, Lit. B, Saint Petersburg, 194156

galagudza@almazovcentre.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации ; Федеральное государственное автономное образовательное учреждение высшего образования «Санкт-Петербургский государственный электротехнический университет “ЛЭТИ” имени В. И. Ульянова (Ленина)»РоссияAlmazov National Medical Research Centre ; Saint Petersburg Electrotechnical University «LETI»Russian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации ; Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre ; Pavlov First Saint Petersburg State Medical UniversityRussian FederationФедеральное государственное унитарное предприятие «Научно-исследовательский институт гигиены, профпатологии и экологии человека» Федерального медико-биологического агентстваРоссияResearch Institute of Hygiene, Occupational Pathology and Human EcologyRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияPediatric Saint Petersburg State Medical UniversityRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации ; Федеральное государственное бюджетное учреждение науки «Институт аналитического приборостроения» Российской академии наукРоссияAlmazov National Medical Research Centre ; Institute for Analytical Instrumentation of the Russian Academy of SciencesRussian Federation202504112025124352372Copyright © Чебуркин Ю.В., Смирнов Е.А., Мурашко Е.А., Королев Д.В., Колобов А.А., Бутко Д.Ю., Ситков Н.О., Галагудза М.М., 20252025Чебуркин Ю.В., Смирнов Е.А., Мурашко Е.А., Королев Д.В., Колобов А.А., Бутко Д.Ю., Ситков Н.О., Галагудза М.М.Cheburkin Y.V., Smirnov E.A., Murashko E.A., Korolev D.V., Kolobov A.A., Butko D.Y., Sitkov N.O., Galagudza M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/1063

Ишемическая болезнь сердца остается одной из наиболее частых причин смерти человека в мире и лидирует в структуре смертности. Ишемически-реперфузионное повреждение миокарда, представляющее собой патогенетическую основу ишемической болезни сердца, включает избыточное образование активных форм кислорода, приводящих к оксидативному повреждению миокарда. Наиболее логичным способом борьбы с избытком активных форм кислорода является использование антиоксидантов, показавших свою эффективность в экспериментальных исследованиях. Однако для системного использования лекарственных средств на основе антиоксидантов в условиях клиники необходимы соответствующие способы их таргетной доставки. В настоящем обзоре рассматриваются механизмы генерации и действия активных форм кислорода при ишемически-реперфузионном повреждении сердца, а также последствия оксидативного повреждения миокарда. Авторами раскрываются принципы направленной доставки антиоксидантов в сердце, основанные как на пассивном способе, так и на активном способе доставки, при котором используются тропные к ишемизированной ткани лиганды, например, таргетные хоуминг-пептиды. Представленный в обзоре анализ результатов различных исследований показывает, что доставка с использованием подобных специфических лигандов может способствовать повышению биодоступности антиоксидантов, а также кардиопротективной эффективности лекарств, созданных на их основе. В будущем использование искусственного интеллекта для дизайна высокоаффинных таргетных пептидов может открыть новые возможности для персонализированной терапии ишемической болезни сердца. Таким образом, разработка систем направленного транспорта лекарственных средств представляет собой одну из наиболее перспективных стратегий для повышения эффективности терапии ишемически-реперфузионного повреждения миокарда.

Coronary heart disease remains one of the leading causes of death worldwide. Myocardial ischaemia-reperfusion injury, the underlying cause of сoronary heart disease, involves the excessive formation of reactive oxygen species, which leads to myocardial oxidative damage. The most logical way to combat excess ROS is to use antioxidants, which have been shown to be effective in experimental studies. However, appropriate targeting delivery methods are needed for the systemic use of antioxidant-based drugs in a clinical setting. This review discusses the mechanisms of ROS generation and action in cardiac сoronary heart disease, as well as the consequences of oxidative damage. The authors present the principles of targeted antioxidant delivery using both passive and active methods involving ligands that are specific to ischaemic tissue, such as targeted homing peptides. Analysis of the results of the various studies presented in this review shows that delivery using such specific ligands may increase the bioavailability of antioxidants and the cardioprotective efficacy of drugs based on them. In the future, the use of artificial intelligence to design high-affinity targeted peptides may open new possibilities for personalized therapy for coronary heart disease. Thus, the development of targeted drug delivery systems represents one of the most promising strategies for improving the effectiveness of treatment for myocardial ischemia-reperfusion injury.

ишемически-реперфузионное повреждение миокардаактивные формы кислородаоксидативный стресскардиопротективный эффектнаправленная доставка лекарственных средствантиоксидантынаночастицытаргетные хоуминг-пептидыmyocardial ischemia-reperfusion injuryreactive oxygen speciesoxidative stresscardioprotective effecttargeted drug deliveryantioxidantsnanoparticlestargeted homing peptidesРабота выполнена в рамках государственного задания ФГБУ «НМИЦ им. В. А. Алмазова» Минздрава России «Разработка метода адресной доставки на основе наноконъюгатов кардио-таргетных пептидов» (рег. №: 124021600063-1) и приоритетного государственного задания ФГБУ «НМИЦ им. В. А. 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The authors declare that there are no conflicts of interest present.