transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2024-11-6-532-545TSJMCPtransmed-1023Research ArticleРЕГЕНЕРАТИВНАЯ МЕДИЦИНАREGENERATIVE MEDICINEРоль взаимодействия остеобластов и остеоцитов в условиях in vivo и в ходе процесса остеодифференцировки in vitro в ключе дальнейших перспектив применения для целей регенеративной медициныThe role of the interaction of osteoblasts and osteocytes in vivo and during the process of osteodifferentiation in vitro in the key of further prospects of application for the purposes of regenerative medicineКовалеваА. А.KovalevaA. A.

Ковалева Анастасия Андреевна - старший лаборант-исследователь лаборатории молекулярной медицины, ФГБУН ИНЦ РАН.

Тихорецкий пр., д. 4, Санкт-Петербург, 194064

Anastasiia A. Kovaleva - senior laboratory technician, Laboratory of molecular medicine, Institute of Cytology of the Russian Academy of Sciences.

Saint Petersburg

lapislapis1999@gmail.comКрасноваО. А.KrasnovaO. A.

Краснова Ольга Александровна - младший научный сотрудник лаборатории молекулярной медицины, ФГБУН ИНЦ РАН.

Санкт-Петербург

Olga A. Krasnova - junior research assistant, Laboratory of molecular medicine, Institute of Cytology of the Russian Academy of Sciences.

Saint Petersburg

НегановаИ. Э.NeganovaI. E.

Неганова Ирина Эриковна - к.б.н., заведующий лабораторией молекулярной медицины, ФГБУН ИНЦ РАН.

Санкт-Петербург

Irina E. Neganova - PhD, head at Laboratory of molecular medicine, Institute of Cytology of the Russian Academy of Sciences.

Saint Petersburg

Федеральное государственное бюджетное учреждение науки «Институт цитологии Российской академии наук»РоссияInstitute of Cytology of the Russian Academy of ScienceRussian Federation202426012025116532545Copyright © Ковалева А.А., Краснова О.А., Неганова И.Э., 20252025Ковалева А.А., Краснова О.А., Неганова И.Э.Kovaleva A.A., Krasnova O.A., Neganova I.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/1023

Заболевания, ассоциированные с нарушением гомеостаза костной ткани, включая остеопороз, находятся среди патологий, которые лидируют по уровню летальности. Разработка и внедрение подходов тканевой инженерии, основанных на применении мезенхимных стволовых клеток, обещают стать высокоэффективным методом их терапии. Однако фундаментальные молекулярно-клеточные механизмы, нарушение которых приводит к развитию заболеваний костной ткани, требуют дополнительных исследований. Взаимодействия между остеобластами и остеоцитами костной ткани, несомненно, играют важную роль в поддержании баланса между процессами формирования кости и вовлечены в патогенез заболеваний костной ткани. Для более углубленного понимания различных аспектов этих взаимодействий необходима репрезентативная модель. Использование клеточных культур человека в качестве составной части такой модели более точно отображает физиологические нюансы, в отличие от клеточных культур, полученных из тканей модельных животных. Возможность создания систем совместного культивирования остеобластов и остеоцитов, полученных из мезенхимных стволовых клеток человека, и их применение в контексте трансляционной медицины находятся в фокусе внимания авторов настоящего обзора.

Pathologies associated with impaired bone homeostasis, including osteoporosis, are among the leading diseases in terms of mortality. The development and implementation of tissue engineering approaches based on the use of human mesenchymal stem cells promises to become a highly effective method for their therapy. However, the fundamental cellular mechanism, which is associated with the development of bone diseases, require an additional study. Interactions between osteoblasts and osteocytes of bone tissue undoubtedly plays an important role in maintaining a balance between the processes of bone formation and resorption and involved in the pathogenesis of certain diseases. For more in-depth understanding of the various aspects of these interactions, a representative model is needed. In contrast to cell cultures obtained from the tissues of animal models, the employment of human mesenchymal stem cell cultures reflects more accurately the physiological and phenotypical nuances in human bone. The possibility of creating systems for the co-cultivation of osteoblasts and osteocytes derived from human mesenchymal stem cells and their application in the context of translational medicine is in the focus of this review.

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The authors declare that there are no conflicts of interest present.